摘要
目的:观察益肾壮阳膏对ED患者阴茎海绵体动脉血流动力学参数的影响,探讨其作用机制。方法:选取门诊92例ED患者,随机分为观察组(n=60)和对照组(n=32),分别予益肾壮阳膏和安慰剂治疗,疗程4周,比较治疗前后IIEF-5评分、阴茎勃起硬度评分(EHS)及阴茎海绵体动脉血流动力学参数。结果:治疗后观察组IIEF-5、EHS较治疗前显著升高[(19.18±3.56)分vs(12.63±3.78)分,(3.58±0.50)分vs(3.21±0.62)分,P均<0.01],且显著高于对照组治疗后评分[(19.18±3.56)分vs(13.72±2.85)分,(3.58±0.50)分vs(3.28±0.58)分,P均<0.01)];但两组间及组内治疗前后阴茎海绵体动脉收缩期峰值流速、舒张末期流速、阻力指数变化均无统计学意义(P均>0.05)。观察组治疗有效率为73.33%,优于对照组的21.88%(Z=-4.665,P<0.01)。结论:益肾壮阳膏对ED患者有较好的改善作用,可以提高阴茎勃起硬度及改善IIEF-5评分。但阴茎血流动力学无明显改变,其作用机制需进一步研究。
Objective: To observe the effect of Yishen Zhuangyang Cream(YZC) on the hemodynamic parameters of the penile cavernous artery in ED patients and explore its pharmacological mechanisms. Methods: Ninety-two outpatients with ED were randomly assigned to receive YZC(n = 60) or placebo( the control group, n = 32), all for 4 weeks. Comparisons were made between the two groups of patients in the IIEF-5 scores, penile erectile hardness(PEH) scores and the hemodynamic parameters of the penile cavernous artery before and after treatment. Results: The IIEF-5 and PEH scores were both significantly increased in the YZC group after treatment in comparison with the baseline(19.18 ± 3.56 vs 12.63 ± 3.78, P < 0.01;3.58 ± 0.50 vs 3.21 ± 0.62, P < 0.01), and higher than in the control group after medication(19.18 ± 3.56 vs 13.72 ± 2.85, P = 0.01;3.58 ± 0.50 vs 3.28 ± 0.58, P < 0.01), but no statistically significances were observed between the two groups after treatment or within each group before and after medication in the peak systolic velocity(PSV), end-diastolic velocity(EDV), or resistance index(RI) of the penile artery(P > 0.05). The rate of therapeutic effectiveness was remarkably higher in the YZC than in the control group(73.33% vs 21.88%, Z =-4.665, P < 0.01). Conclusion: YZC can improve the erectile function of ED patients by increasing IIEF-5 and PEH scores but has no significant effect on penile hemodynamics. The pharmacological mechanisms of YZC acting on ED need to be further studied.
作者
黄存超
HUANG Cun-chao(Department of Andrology,Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning,Guangxi 530011,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2019年第2期160-163,共4页
National Journal of Andrology
基金
广西中医药大学青年基金(2015MS018)~~
关键词
勃起功能障碍
益肾壮阳膏
阴茎血流动力学
临床疗效
erectile dysfunction
Yishen Zhuangyang Cream
penile hemodynamics
clinical effect
作者简介
通讯作者:黄存超(1981-),男,壮族,广西贵港市人,主治医师,硕士,从事男科学专业。Email:45914940@qq.com.
