摘要
目的 探讨层粘连蛋白 (LN)在直肠癌组织中的表达特点。方法 应用免疫组化法对 31例直肠癌 ,5例直肠腺瘤病人的LN进行了检测 ,并分析其与临床及病理学指标间的关系。结果 LN在 5例直肠腺瘤中完整表达 ,在 31例直肠癌中仅 16例有完整或部分表达 ,两者比较差异有显著性 (P <0 .0 5 )。LN在直肠癌浸润深度方面差异亦有显著性 (P <0 .0 5 ) ,而在病人的年龄、性别、淋巴结转移、远处转移、肿块外形、肿瘤的病理类型及分级方面差异无显著性 (P >0 .0 5 )。结论 直肠癌病人LN与其浸润深度有关 。
Objective To investigate the expression of LN in rectal carcinoma.Methods The LN in rectal carcinoma of 31 cases and in rectal adenoma of 5 cases was examined with immunohistochemistry,and analysis was done to find out the relationship between its expression and clinical or pathological data.Results The rectal adenoma of 5 cases had complete expression of LN while only 16 in 31 rectal carcinoma cases had complete or part expression of LN.Therefore,there was a significant difference between them(P<0.05).The expression of LN caused a significant difference in terms of invasive extent(P<0.05),but no significant difference in terms of age,sex,the shape of tumor,lymphatic metastasis and distant metastasis,histological type and pathological grade(P>0.05).Conclusion The expression of LN in rectal carcinoma,which is closely related to its invasive depth,can be regarded as an important factor for the prognosis of rectal carcinoma.
出处
《潍坊医学院学报》
2003年第2期114-115,共2页
Acta Academiae Medicinae Weifang
