摘要
由计算机辅助设计.以Fmoc-AA-Pfp为单体,用固相法合成了a-h-ANF及其两种类似物,产率较高.兔心血管收缩试验表明,两种类似物的血管舒张活性均高于a-h-ANF.
Based upon a structural working model for ANF's functioning mechanism,two analogs of α-h-ANF were designed.Using Fmoc-AA-Pfp as monomer,α-h-ANF and its analogs cited above were synthesized by a solid phase procedure with a high yield and purity.The biological activity study of rabbit aorta shows that one of the analogs is twice and another about one and a half times more active than α-h-ANF itself.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1992年第10期1247-1250,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
固相多肽合成
生物活性
α-h-ANF
α-h-ANF analogs,Solid phase polypeptide synthesis,Computer-auxiliary molecular design,Biological activity
