摘要
采用Fmoc固相合成法,选用2-氯三苯甲基氯树脂作为固相载,HBTU/HOBt和HATU/HOBt为缩合剂,合成全保护线性肽。以V(DCM)∶V(THF)=1∶1为溶剂,HATU/HOBt为缩合剂,合成全保护环肽。最后脱除保护基得终产物西仑吉肽。
Fully-protected linear peptide was synthesized by Fmoc solid phase peptide synthesis methods. The solid phase carrier was 2-chlorotrityl chloride resin. HATU/HOBt and HBTU/HOBt were used as the coupling reagents. The synthe- sis of fully-protected cyclic peptide used THF/DCM （ at a ra- tio of 1：1 by volume） as the solvent and HATU/HOBt as the coupling reagents. Finally cilengitide could be obtained by deprotection reaction.
出处
《化学试剂》
CAS
CSCD
北大核心
2012年第11期1041-1042,1046,共3页
Chemical Reagents
关键词
固相多肽合成
环肽
2-氯三苯甲基氯树脂
西仑吉肽
solid phase peptide synthesis
cyclic peptide
2-chlorotrityl chloride resin
cilengitide
作者简介
作者简介：张波（1986-），男，江苏常州人，硕士，主要从事多肽合成研究
通讯作者：姚忠，E—mail：yaozhong@njut．edu．cn。
