摘要
本文报道采用毛细管胶束电动色谱法对复方药物去痛片和感冒灵中有效成分进行了分离和定量研究。以0.05毫米内径、45厘米长的弹性石英毛细管为分离柱,用十二烷基硫酸钠胶束溶液,在选定的实验条件下,各组分在十几分钟内就能很好的分离。采用两点内标法定量,所得结果与HPLC法测定结果相一致。该法具有装置简单,无需价格昂贵的分离柱,样品预处理简单等优点,可在药物分析中推广。
When a fused sillica capillary, 450mm×0.05mm i. d., is used as the separation column
and sodium dodecyl sulfate (SDS) is used as the micellar solution, the active ingredients of
some compound drugs can be well separated within several 10 minutes. The results obtained by
two-points internal standard are in good agreement with those obtained by HPLC, therefore
it is suited in drug analysis for it's inexpensive and simple apparatus and no sample pretreat-
ment is required.
关键词
药物分析
毛细管
胶束电动色谱
Micellar electrokinetic capillary chromatography
Sodium dodecyl sulfate
Drug analysis
