摘要
目的 :采用反相高效液相色谱法以程序变换控制记录积分衰减因子的方法 ,测定复方美愈缓释片中愈创木酚甘油醚和氢溴酸右美沙芬的含量。方法 :色谱柱为 Shimadzu VP-ODS(15 0 mm× 4.6mm) ,流动相为乙腈 -甲醇 -0 .0 1mol/ L 的三乙胺水溶液 (PH=3 .5 ) (18∶ 15∶ 67) ,检测波长 :2 76nm,流速为 1.0 ml/ m in。结果 :愈创木酚甘油醚和氢溴酸右美沙芬线性范围分别为 5 5 .9～ 782 .6μg/ ml和 4.2～ 5 8.8μg/ ml,平均回收率分别为 98.99% ,RSD1.2 % (n=7) ;10 2 .9% ,RSD 1.6% (n=7)。结论
OBJECTIVE:To develop HPLC method for the determination of Guaifenesin and Dextromethorphan Hydrobromide in Sustained release tablets. METHOD:The measurement condition used are as follows: Shimadzu VP ODS(150×4.6mm 5μ)column; Mobile phase:Acetonitrile Methanol 0.01mol/l Triethylamine solution (adsust with H 3PO 4 PH=3.5)= 18∶15∶67; Flow rate:1.0ml/min;Wavelength:276nm.RESULTS:The recovery rates for Guaifenesin and Dextromethorphan Hydrobromide were 98.99%?102.9% respectively and all RSD were less than 2.0%.CONCLUSION:The procedure is simple and rapid. The method can be used for quality control.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2002年第6期491-492,共2页
Chinese Journal of Modern Applied Pharmacy
