摘要
目的系统评估中医药治疗干眼的循证医学证据,分析其疗效及与现代西医治疗的差异,为临床应用提供科学依据。方法通过检索中英文数据库(包括中国知网、万方数据、PubMed、Cochrane Library等),纳入中医药治疗干眼的Meta分析及系统评价文献。按照严格的纳入和排除标准筛选文献,提取相关数据并进行整合分析。采用Mantel-Haenszel固定效应模型计算相对危险度(RR)及均数差(WMD),以95%置信区间表示效应量,分析中医药治疗干眼的疗效指标。结果最终纳入21篇文献,涉及中医药治疗干眼的多种干预措施(如中药、针灸、中医外治法等)。结果显示,中医药治疗在提高临床总有效率[RR=1.63,95%CI(1.46,1.81),P<0.05]、延长泪膜破裂时间[MD=2.23,95%CI(1.85,2.60),P<0.05]、增加泪液分泌量[MD=1.49,95%CI(1.04,1.94),P<0.05]等方面均优于单纯西药治疗。此外,针灸、中药联合西药及中医外治法等治疗方式在改善干眼状和泪液功能方面均表现出独特优势。结论中医药治疗干眼在临床总有效率、泪膜破裂时间、泪液分泌量等关键指标上显示出显著疗效,且安全性较高。
Objective This study aims to systematically evaluate the evidence-based medicine of traditional Chinese medicine(TCM)in the treatment of dry eye,analyze its efficacy and differences compared with modern Western medicine treatments,and provide a scientific basis for clinical application.Methods By searching Chinese and English databases(including CNKI,Wanfang Data,PubMed,Cochrane Library,etc.),we included meta-analyses and systematic reviews of TCM treatments for dry eye.Literature was screened according to strict inclusion and exclusion criteria,and relevant data were extracted and integrated for analysis.The Mantel-Haenszel fixed-effects model was used to calculate the relative risk(RR)and mean difference(WMD),with the effect size expressed as a 95%confidence interval,to analyze the efficacy indicators of TCM treatment for dry eye.Results A total of 21 articles were finally included,involving various TCM interventions for dry eye(such as Chinese herbal medicine,acupuncture,and TCM external therapies).The results showed that TCM treatment was superior to Western medicine alone in improving the overall clinical efficacy[RR=1.63,95%CI(1.46,1.81),P<0.05],prolonging tear film break-up time[MD=2.23,95%CI(1.85,2.60),P<0.05],and increasing tear secretion[MD=1.49,95%CI(1.04,1.94),P<0.05].In addition,acupuncture,the combination of Chinese herbal medicine and Western medicine,and TCM external therapies all demonstrated unique advantages in improving dry eye symptoms and tear function.Conclusion TCM treatment for dry eye shows significant efficacy in key indicators such as overall clinical efficacy,tear film break-up time,and tear secretion,with a high level of safety.
作者
令娟
韩雪
胡梅
杨雪
李嘉进
代明丽
庄家园
高英
胡亦明
杨芮
康莉
雷迅文
罗向霞
LING Juan;HAN Xue;HU Mei;YANG Xue;LI Jiajin;DAI Mingli;ZHUANG Jiayuan;GAO Ying;HU Yiming;YANG Rui;KANG Li;LEI Xunwen;LUO Xiangxia(Gansu Provincial People’s Hospital,Lanzhou 730000,Gansu Province,China;School of Traditional Chinese Clinical Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu Province,China)
出处
《眼科新进展》
北大核心
2025年第11期888-896,共9页
Recent Advances in Ophthalmology
基金
国家自然科学基金项目(编号:8236150800)
甘肃省自然科学基金项目(编号:24JRRA566)
甘肃省省级人才项目[编号:甘组通字(2024)4号]
甘肃省高校研究生“创新之星”项目(编号:2025CXZX-911)
甘肃省科技计划项目优秀博士生项目(编号:24JRRA614)
甘肃省拔尖领军人才项目[编号:省委人才小组发(2024)12号]
甘肃省药品监督管理局科研项目(编号:2025GSMPA064)
甘肃省名中医罗向霞传承工作室建设项目。
关键词
中医药
干眼
循证证据评价
traditional Chinese medicine
dry eye
evaluation of evidence-based evidence
作者简介
令娟(ORCID:0000-0002-7021-888),女,1994年8月出手,甘肃兰州人,在读博士研究生,住院医师。研究方向:眼科疾病。E-mail:2276299207@qq.com;通信作者:罗向霞(ORCID:0009-0004-6550-8582),女,1975年4月出生,甘肃兰州人,博士生导师。研究方向:中医药治疗眼病。E-mail:279089608@qq.com。
