摘要
胶原膜因具有来源广、可降解吸收、免疫原性低等优良特性而备受研究者关注,但存在机械稳定性差、降解速度过快等缺点。为提升其理化性质与生物学功能,研究人员开发了交联、搭载生长因子或药物、与其他优良材料复合、优化其成分与结构、用海洋胶原蛋白替代等方法,以拓宽其在口腔医学方面的应用。口腔医学领域对高性能生物材料的需求迫切,通过总结胶原膜在口腔医学领域的应用进展,深入剖析其作用机制、临床疗效及局限性,可为优化胶原膜设计和拓展其临床应用提供参考。同时,进一步探讨结合先进制造技术、开发个性化胶原膜的未来研究趋势,可为提升口腔疾病治疗效果贡献力量。
Collagen membrane has attracted much attention from researchers due to its excellent properties such as wide source,degradable absorption,and low immunogenicity.However,they are limited by poor mechanical stability and rapid degradation.To enhance their physicochemical properties and biological functions,researchers have developed various strategies,including cross-linking,incorporation of growth factors or drugs,combination with other biomaterials,optimization of composition and structure,and substitution with marine-derived collagen.These advances aim to expand the clinical applications of collagen membranes in oral medicine.With the urgent demand for high-performance biomaterials in oral medicine,summarizing recent progress on collagen membranes provides valuable insights into their mechanisms,clinical efficacy,and limitations,offering reference for optimized design and broader clinical use.Furthermore,further trends may include integrating advanced manufacturing technologies to develop personalized collagen membranes,which could significantly improve therapeutic outcomes in oral diseases.
作者
王奕钦
温珺俍
于新航
陈珺
李文杰
WANG Yiqin;WEN Junliang;YU Xinhang;CHEN Jun;LI Wenjie(Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine,Hunan Key Laboratory of Oral Health Research,Hunan 3D Printing Engineering Research Center of Oral Care,Hunan Clinical Research Center of Oral Major Diseases and Oral Health,WANG Songling Academician Workstation for Oral maxillofacial and Regenerative Medicine,Xiangya School of Stomatology,Central South University,Changsha 410008;Department of Periodontology,Xiangya Stomatological Hospital,Central South University,Changsha 410008;Department of Orthodontics,Xiangya Stomatological Hospital,Central South University,Changsha 410008,China)
出处
《中南大学学报(医学版)》
北大核心
2025年第6期1088-1098,共11页
Journal of Central South University (Medical Science)
基金
国家重点研发计划(2024YFB3815004)
湖南省自然科学基金项目(2024JJ5506)
长沙市自然科学基金项目(kq2403114)
中南大学前沿交叉研究项目(2023QYJC036)
中南大学湘雅口腔医院医疗新技术新业务项目(2023JS01)。
关键词
胶原膜
牙周炎
骨再生
角化黏膜
上颌窦穿孔
骨缺损
味觉出汗综合征
牙髓再生
collagen membrane
periodontitis
bone regeneration
keratinized mucosa
maxillary sinus perforation
bone defects
gustatory sweating syndrome
pulp regeneration
作者简介
第一作者:王奕钦,Email:wyq0819jqq@163.com,ORCID:0009-0002-7442-524X;通信作者:李文杰,副主任医师,Email:liwenj@csu.edu.cn,ORCID:0000-0003-4195-6351。
