摘要
目的探讨血清和龈沟液中低氧诱导因子-1α(HIF-1α)及白介素-1β(IL-1β)的表达水平与老年牙隐裂伴慢性牙髓炎患者炎症因子水平和治疗效果的相关性。方法收集山东省东营市人民医院2020年1月—2024年1月收治的80例老年牙隐裂伴慢性牙髓炎患者的临床资料,根据治疗效果分为疗效良好组(n=55)与疗效不良组(n=25)。收集所有患者治疗前血清和龈沟液中HIF-1α、IL-1β表达水平及血清肿瘤坏死因子-α(TNF-α)和C反应蛋白(CRP)水平,比较不同疗效患者的血清和龈沟液HIF-1α、IL-1β表达水平;采用Pearson相关分析探讨血清和龈沟液中HIF-1α、IL-1β表达水平与TNF-α和CRP水平的相关性;采用多因素logistic回归分析影响老年牙隐裂伴慢性牙髓炎患者疗效的相关因素。结果2组患者的性别构成、牙龈裂病程、慢性牙髓炎病程、合并症情况比较,差异均无统计学意义(P>0.05);疗效不良组患者年龄大于疗效良好组,差异有统计学意义(P<0.05)。2组患者血清HIF-1α、IL-1β水平比较,差异均无统计学意义(P>0.05);疗效不良组患者龈沟液HIF-1α、IL-1β表达水平以及血清TNF-α、CRP水平均高于疗效良好组,差异均有统计学意义(P<0.05)。多因素分析结果显示,老年牙隐裂伴慢性牙髓炎患者龈沟液HIF-1α、IL-1β水平与临床疗效有关(P<0.05),而年龄与临床疗效无显著相关性(P>0.05)。相关性分析结果显示,老年牙隐裂伴慢性牙髓炎患者血清和龈沟液HIF-1α、IL-1β表达水平与TNF-α、CRP水平均呈正相关(P<0.05)。结论老年牙隐裂伴慢性牙髓炎患者的治疗效果与龈沟液HIF-1α及IL-1β表达水平密切相关,且血清和龈沟液HIF-1α、IL-1β表达水平与TNF-α、CRP水平均呈正相关。因此,临床上可持续监测TNF-α、CRP水平,从而为临床评估治疗效果及制定个体化治疗策略提供参考。
Objective To investigate the relationship between serum and gingival crevicular fluid(GCF)expression levels of hypoxia-inducible factor-1α(HIF-1α)and interleukin-1β(IL-1β)and both inflammatory marker levels and treatment outcomes in elderly patients with cracked tooth complicated by chronic pulpitis.Methods Clinical data were collected from 80 elderly patients with cracked tooth complicated by chronic pulpitis who were treated at Dongying People′s Hospital from January 2020 to January 2024.Patients were categorized according to treatment outcome into a good-outcome group(n=55)and a poor-outcome group(n=25).Pre-treatment serum and GCF levels of HIF-1αand IL-1β,as well as serum tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)were measured.Serum and GCF HIF-1αand IL-1βlevels were compared between outcome groups.Pearson correlation analysis was used to examine relationships of serum with GCF HIF-1α/IL-1βexpression levels,TNF-αlevels,and CRP levels.Multivariate logistic regression was performed to identify factors associated with treatment outcome.Results No significant differences between the two groups were noted in sex distribution,duration of the gingival fissure,duration of chronic pulpitis,or comorbidity status(P>0.05).Patients in the poor-outcome group were significantly older than those in the good-outcome group(P<0.05).Serum HIF-1αand IL-1βlevels did not differ significantly between groups(P>0.05).However,GCF HIF-1αand IL-1βexpression levels and serum TNF-αand CRP levels were higher in the poor-outcome group than in the good-outcome group,and these differences were statistically significant(P<0.05).Multivariate analysis indicated that GCF HIF-1αand GCF IL-1βlevels were associated with treatment outcome(P<0.05),whereas age was not significantly associated with treatment outcome(P>0.05).Correlation analysis showed that serum and GCF HIF-1αand IL-1βexpression levels were positively correlated with TNF-αand CRP levels(P<0.05).Conclusion In elderly patients with cracked tooth complicated by chronic pulpitis,treatment outcome is closely correlated with GCF HIF-1αand IL-1βexpression levels.Serum and GCF HIF-1αand IL-1βexpression levels are positively correlated with TNF-αand CRP levels.Continuous clinical monitoring of TNF-αand CRP levels may therefore help evaluate treatment outcomes and guide individualized therapeutic strategies.
作者
李磊磊
孟德廷
王晓丽
王锦凤
于磊
杨云
隋晓栋
王玉美
Li Leilei;Meng Deting;Wang Xiaoli;Wang Jinfeng;Yu Lei;Yang Yun;Sui Xiaodong;Wang Yumei(Department of Stomatology,Dongying People′s Hospital,Dongying Shandong 257091,China;Department of Stomatology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250000,China;Department of Stomatology,Dongcheng Hospital,Dongying Shandong 257091,China;Department of Stomatology,Liaocheng Hospital of Traditional Chinese Medicine,Liaocheng Shandong 252000,China;Department of Stomatology,The People′s Hospital of Dongying District,Dongying Shandong 257000,China)
出处
《保健医学研究与实践》
2025年第6期72-77,共6页
Health Medicine Research and Practice
基金
山东省中医药科技项目(M-2022121)。
作者简介
第一作者:李磊磊,E-mail:18805463968@163.com;通信作者:王玉美,E-mail:wjl13780780083@163.com。
