摘要
【目的】探讨补阳还五汤联合依达拉奉右莰醇注射液治疗急性脑梗死(ACI)的疗效。【方法】90例ACI患者,随机分为对照组与观察组,每组45例。对照组采用依达拉奉右莰醇注射液治疗,观察组在对照组基础上联合补阳还五汤治疗。比较两组治疗前后颈动脉内中膜厚度、斑块面积、中医证候积分、神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)评分]、生活质量[改良Rankin量表(MRS)评分],以及血清脂蛋白相关磷脂酶A2(Lp-PLA2)、神经元特异性烯醇化酶(NSE)水平。【结果】治疗后,观察组颈动脉内中膜厚度、斑块面积、中医证候各项积分、NIHSS评分、MRS评分、Lp-PLA2和NSE水平均低于对照组(P<0.05)。【结论】补阳还五汤联合依达拉奉右莰醇注射液治疗ACI能够有效减轻患者颈动脉病变程度,改善临床症状及神经功能状态,提升生活质量,降低Lp-PLA2与NSE水平,值得临床推广应用。
【Objective】To investigate the clinical efficacy of Buyang Huanwu Decoction combined with edaravone dexborneol injection in the treatment of acute cerebral infarction(ACI).【Methods】A total of 90 ACI patients were randomly divided into the control group and the observation group,with 45 cases in each group.The control group received edaravone dexborneol injection,while the observation group received BYHWD in addition to the same treatment as the control group.Changes in carotid intima-media thickness(IMT),plaque area,Traditional Chinese Medicine(TCM)syndrome score,neurological deficit[National Institutes of Health Stroke Scale(NIHSS)score],quality of life[Modified Rankin Scale(MRS)score],and serum levels of lipoprotein-associated phospholipase A2(Lp-PLA2)and neuron-specific enolase(NSE)were compared between the two groups before and after treatment.【Results】After treatment,the observation group showed significantly lower carotid IMT,plaque area,TCM syndrome score,NIHSS score,mRS score,Lp-PLA2,and NSE levels compared to the control group(P<0.05).【Conclusion】Buyang Huanwu Decoction combined with edaravone dexborneol injection can effectively alleviate arterial lesions,improve TCM symptoms and neurological function,enhance quality of life,and reduce serum Lp-PLA2 and NSE levels in ACI patients,making it worthy of clinical promotion.
作者
朱腾西
暴党振
ZHU Tengxi;BAO Dangzhen(Department of Neurology,Puyang Pingyuan Hospital,Puyang Henan 457000)
出处
《医学临床研究》
2025年第8期1388-1390,1394,共4页
Journal of Clinical Research
关键词
脑梗死
急性病
补阳还五汤
依达拉奉
治疗结果
Brain Infarction
Acute Disease
Buyang Huanwutang
Edaravone
Treatment Outcome
