摘要
目的:观察龟鹿二仙汤加味治疗恶性肿瘤化疗后所致血小板减少症的临床疗效。方法:将100例恶性肿瘤化疗后所致血小板减少症患者,按照随机数字表法分为治疗组和对照组,每组各50例。对照组给予重组人白介素-11,治疗组在对照组治疗的基础上给予龟鹿二仙汤加味治疗。比较两组患者的临床疗效、血小板计数(platelet, PLT)恢复正常时间及重组人白介素-11用量,记录两组患者头晕、乏力、心悸、白细胞计数降低、房颤、贫血等不良反应的发生情况,比较两组患者治疗前后生存质量评分及血虚症状评分变化情况。结果:对照组有效率为66.0%,治疗组有效率为86.0%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后血小板计数高于本组治疗前,且治疗后治疗组高于对照组(P<0.05)。治疗组PLT恢复正常时间明显短于对照组,且重组人白介素-11使用量明显少于对照组,差异具有统计学意义(P<0.05)。治疗组白细胞计数降低比例及贫血发生例数明显低于对照组(P<0.05)。两组患者治疗后各项生存质量评分、血虚症状积分低于本组治疗前,且治疗后治疗组低于对照组,差异具有统计学意义(P<0.05)。结论:龟鹿二仙汤加味治疗恶性肿瘤化疗后所致血小板减少症,临床疗效确切,可升高血小板计数及白细胞计数,改善贫血症状,提高患者生存质量。
Objective:To observe the clinical efficacy of Supplemented Tortoise Shell and Deer Horn Two Immortals Plaster on chemotherapy-induced thrombocytopenia(CIT)in malignant tumors.Methods:A total of 100 hospitalized patients with CIT in malignant tumors were randomly divided into the treatment group and the control group using the random number table method,with 50 cases in each group.The control group received recombinant human interleukin-11(rhIL-11),while the treatment group received Supplemented Tortoise Shell and Deer Horn Two Immortals Plaster in addition to the control group′s treatment.Clinical efficacy,time for platelet(PLT)recovery to normal levels,rhIL-11 dosage,and adverse reactions such as dizziness,fatigue,palpitations,leukopenia,atrial fibrillation,anemia,etc.were recorded.Changes in quality of life(QOL)scores and blood deficiency symptom scores before and after treatment were compared between the two groups.Results:The effective rate was 86.0%in the treatment group versus 66.0%in the control group,with a statistically significant difference(P<0.05).After treatment,PLT counts increased significantly in both groups compared to pre-treatment levels,with higher counts in the treatment group than in the control group(P<0.05).The treatment group showed shorter PLT recovery time and reduced rhIL-11 dosage compared to those of the control group,with statistically significant differences(P<0.05).The proportion of leukopenia was significantly lower in the treatment group than that in the control group(P<0.05),,and the number of cases with anemia in the treatment group was significantly lower than that in the control group(P<0.05).The QOL scores and the total scores of blood deficiency symptoms in both groups were lower than those before treatment,and the treatment group′s above indicators were lower than those of the control group,with statistically significant differences(P<0.05).Conclusion:Supplemented Tortoise Shell and Deer Horn Two Immortals Plaster demonstrates definite efficacy in treating CIT in malignant tumors.It can elevate platelet and leukocyte counts,alleviate anemia,and improve QOL of patients.
作者
王影利
徐涛
张威
WANG Yingli;XU Tao;ZHANG Wei(Suixian County Hospital of Traditional Chinese Medicine,Suixian,Henan,China,476900;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan,China,450001;The Third Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450000)
出处
《河南中医》
2025年第9期1418-1422,共5页
Henan Traditional Chinese Medicine
基金
2022年河南省医学科技攻关联合共建项目(LHGJ20221159)。
关键词
血小板减少症
龟鹿二仙汤加味
重组人白介素-11
中西医结合疗法
恶性肿瘤
化疗
thrombocytopenia
Supplemented Tortoise Shell and Deer Horn Two Immortals Plaster
recombinant human interleukin-11(rhIL-11)
integrated traditional Chinese and Western medicine therapy
malignant tumors
chemotherapy
作者简介
王影利(1982-),女,河南焦作人,医学硕士,副主任医师。
