摘要
目的探讨复发性流产(recurrent spontaneous abortion,RSA)风险与阴道分泌物检测指标的相关性。方法回顾性分析2022年3月至2023年1月新疆医科大学第五附属医院收治的150例自然流产患者的临床资料,并按照自然流产次数分为A组[n=50,自然流产1次(含本次妊娠),非RSA患者]、B组[n=50,自然流产2次(含本次妊娠),RSA患者]、C组[n=50,自然流产3次(含本次妊娠),RSA患者];另选取本院同期50名既往及本次均无自然流产史的正常妊娠孕妇作为D组。检测并比较4组阴道分泌物四项指标[过氧化氢(H_(2)O_(2))、白细胞酯酶(leukocyte esterase,LE)、凝固酶和念珠菌],采用多因素Logistic回归分析阴道分泌物四项指标与RSA的相关性。结果4组H_(2)O_(2)、LE、凝固酶、念珠菌检测结果比较差异有统计学意义(P<0.05);A组、B组、C组H_(2)O_(2)、LE、凝固酶检测结果均差于D组,且C组H_(2)O_(2)、LE、凝固酶均差于A组、B组,念珠菌阳性率高于A组、D组,差异有统计学意义(P<0.05),其他组间H_(2)O_(2)、LE、凝固酶检测结果及念珠菌阳性率两两比较差异均无统计学意义。多因素Logistic回归分析结果显示,凝固酶与RSA无关(P=0.805),H_(2)O_(2)[OR(95%CI):2.686(1.978~3.651)]、LE[OR(95%CI):1.652(1.274~2.143)]、念珠菌[OR(95%CI):2.713(1.024~7.185)]均与RAS有关,其中念珠菌的风险最高。结论RSA患者阴道分泌物中H_(2)O_(2)、LE、凝固酶和念珠菌异常升高,H_(2)O_(2)、LE和念珠菌与RSA风险显著相关,其中念珠菌风险最高。
Objective To investigate the correlation between the risk of recurrent spontaneous abortion(RSA)and vaginal secretion detection indicators.Methods The clinical data of 150 patients with spontaneous abortion admitted to The Fifth Affiliated Hospital of Xinjiang Medical University from March 2022 to January 2023 were retrospectively analyzed,they were divided into the group A(n=50,spontaneous abortion 1 time[including this pregnancy]),[non-RSA patients],the group B(n=50,spontaneous abortion 2 times[including this pregnancy],RSA patients),the group C(n=50,spontaneous abortion 3 times[including this pregnancy],RSA patients)according to the number of abortion abortions,another 50 normal pregnant women with no history of abortion from our hospital during the same period were selected as the group D.Four indicators of vaginal secretions(hydrogen peroxide[H_(2)O_(2)],leukocyte esterase[LE],coagulase and Candida)in the four groups were detected and compared,multivariate Logistic regression was used to analyze the correlation between the four indicators of vaginal secretions and RSA.Results There were statistically significant differences in the detection results of H_(2)O_(2),LE,coagulase and Candida among the four groups(P<0.05);the results of H_(2)O_(2),LE,coagulase in the group A,group B and group C were worse than those in the group D,and the results of H_(2)O_(2),LE and coagulase in the group C were worse than those in the group A and group B,the positive rate of Candida in the group C was higher than that in the group A and group D,the differences were statistically significant(P<0.05);there were no statistically significant differences in the results H_(2)O_(2),LE,coagulase and the positive rate of Candida pairwise comparisons among other groups.The results of multivariate Logistic regression analysis showed that coagulase was not associated with RSA(P=0.805),H_(2)O_(2)(OR[95%CI]:2.686[1.978-3.651]),LE(OR[95%CI]:1.652[1.274-2.143]),and Candida(OR[95%CI]:2.713[1.024-7.185])were all associated with RSA,among which Candida had the highest risk.Conclusion H_(2)O_(2),LE,coagulase and Candida were abnormally elevated in vaginal secretions of RSA patients,and H_(2)O_(2),LE and Candida were significantly associated with the risk of RSA,while the risk of Candida was the highest.
作者
吴睿嘉
陈海燕
陈艺文
潘泓宇
WU Ruijia;CHEN Haiyan;CHEN Yiwen;PAN Hongyu(The Fifth Clinical College of Xinjiang Medical University,Urumqi,Xinjiang,830063,China;Department of Obstetrics and Gynecology,The Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang,830063,China)
出处
《当代医学》
2025年第5期36-40,共5页
Contemporary Medicine
基金
新疆维吾尔自治区自然科学基金面上项目(2021D01C422)。
作者简介
通信作者:陈海燕,E-mail:1272787693@qq.com。
