摘要
Young women’s physical and mental health is seriously impacted by recurrent spontaneous abortion(RSA),a prevalent obstetric complication that is becoming more commonplace worldwide.Therefore,a thorough investigation into the pathophysiology of RSA and the development of novel therapeutic strategies are imperative.Recent developments suggest that mesenchymal stem cell(MSC)-based therapies may be viable for addressing RSA.Through a variety of mechanisms,the immunological circumstances at the maternal-fetal contact can be altered,including regulating immune cell homeostasis,enhancing immune tolerance,alleviating inflammatory responses,promoting angiogenic processes,and promoting tissue regeneration.MSCs exhibit a remarkable capacity for multidifferentiation that could enhance pregnancy outcomes.This article provides compelling studies supporting the efficacy of MSC-based therapies in improving pregnancy outcomes in women with RSA.
基金
Supported by the Natural Science Foundation of Liaoning Province,No.2024-MSLH-525.
作者简介
Co-first authors:Yi Xiao;Co-first authors:Fan-Yu Zeng;Corresponding author:Jing-Li Sun,Chief Physician,Department of Obstetrics and Gynecology,General Hospital of Northern Theater Command(Heping Campus),No.5 Guangrong Street,Heping District,Shenyang 110000,Liaoning Province,China.zg3416@sina.com,0000-0003-1285-7645.
