摘要
目的探究集采药品多巴丝肼治疗帕金森病的临床综合价值。方法选取本院2020年1月至2025年1月的500例帕金森病患者深入研究,从安全性、有效性、适宜性几个维度分析多巴丝肼治疗效果。首先通过专家咨询法与文献调研法构建临床综合评价指标体系,再通过德尔菲法与层次分析法进行指标筛选及权重确定;采用文献调研法、真实世界研究法、问卷调查法等构建临床综合评价证据集合体,据此评估多巴丝肼药物,同时依据指标权重对多巴丝肼与美多芭药品临床综合评分有效计算。结果本文构建了多巴丝肼药品临床综合评价指标体系,通过对不同等级的指标(共52个,分三级)分析,同时采用专家咨询表全面计算,共发放两次专家咨询表,第一次回收率为94.45%,第二次回收率为100%;咨询结果可靠性较高。从多巴丝肼的临床综合评价结果分析发现,集采的多巴丝肼药品临床综合评分更高,进口原研药品临床综合评分稍低;从安全性和有效性的分析结果来看,进口原研药品具有较高的安全性与有效性,与集采的多巴丝肼药品从安全性与有效性方面略有不同;从两种药品适宜性比较分析发现,集采的多巴丝肼药品稍高,但与进口原研药相比仅略有优势,总体处于相当水平。结论在帕金森病治疗中,集采药品多巴丝肼临床综合价值与进口原研药品临床综合价值均较高,其中集采的多巴丝肼药品总临床价值高于进口原研药品,临床应用价值较高。临床医师在应用此药品时可依据患者具体情况合理使用。
Objective To explore the clinical comprehensive value of collecting levodopa and benserazide in the treatment of Parkinson’s disease.Methods A total of 500 patients with Parkinson’s disease in our hospital from January 2020 to January 2025 were selected for indepth study,and the therapeutic effect of levodopa and benserazide was analyzed from several dimensions including safety,efficacy and suitability.Firstly,the clinical comprehensive evaluation index system was constructed through the expert consultation method and literature research method.Then,the Delphi method and the analytic hierarchy process were used for index screening and weight determination.The evidence collection for clinical comprehensive evaluation was constructed by using methods such as literature review,real-world research,and questionnaire survey.Based on this,the drug levodopa and benserazide was evaluated.Meanwhile,the clinical comprehensive scores of levodopa and benserazide and medoba drugs were effectively calculated according to the index weights.Results In this paper,the clinical comprehensive evaluation index system of levodopa and benserazide drugs was established.Through the analysis of different grades of indicators(52,divided into three grades)and the comprehensive calculation by using expert consultation tables,the expert consultation tables were distributed twice,with the first recovery rate of 94.45%and the second recovery rate of 100%.The consultation results are highly reliable.From the analysis of the low clinical comprehensive evaluation of levodopa and benserazide,it is found that the clinical comprehensive evaluation of the collected levodopa and benserazide is higher,and the clinical comprehensive evaluation of the imported original drug is slightly lower,From the analysis of low safety and effectiveness,it is found that the imported original research drugs have high safety and effectiveness,which is slightly different from the collected levodopa and benserazide drugs in terms of safety and effectiveness,From the comparative analysis of the suitability of the two drugs,it is found that the collected levodopa and benserazide drug is slightly higher,but it has only a slight advantage compared with the imported original drug,and it is at a considerable level in general.Conclusions In the treatment of Parkinson’s disease,the clinical comprehensive value of collected levodopa and benserazide is higher than that of imported original drugs.The total clinical value of collected levodopa and benserazide is higher than that of imported original drugs,and the clinical application value is higher.The clinician can be assured to use this drug according to the specific situation of the patient.
作者
黄伟
HUANG Wei(Department of Pharmacy,Le’an County People’s Hospital of Jiangxi Province,Fuzhou,Jiangxi 344300,China)
出处
《中国医药指南》
2025年第22期104-107,共4页
Guide of China Medicine
基金
江西省第二批药品临床综合评价项目课题。
关键词
帕金森病
集采药品
多巴丝肼
临床综合评价
有效性
安全性
Parkinson’s disease
Volume-based procurement drugs
levodopa and benserazide
Clinical comprehensive evaluation
Effectiveness
Safety
