摘要
目的 观察中西医结合治疗小儿腹泻的临床疗效及对肠道微生态平衡和炎症因子表达的影响。方法 将96例腹泻患儿按照随机数字表法分为2组,每组48例,对照组予常规西医治疗,研究组予中西医结合治疗。比较2组症状恢复情况、治疗前后中医证候评分、肠道菌群、肠黏膜屏障功能[二胺氧化酶(DAO)、D-乳酸、内毒素]、炎症因子水平[肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、C反应蛋白(CRP)]及临床疗效。结果 研究组总有效率95.83%(46/48),对照组总有效率77.08%(37/48),研究组总有效率高于对照组(P<0.05)。研究组各症状恢复时间均短于对照组(P<0.05)。2组治疗后中医证候各项评分均较本组治疗前降低(P<0.05),且研究组治疗后均低于对照组(P<0.05)。2组治疗后肠道乳杆菌、双歧杆菌、肠球菌均升高(P<0.05),肠杆菌均降低(P<0.05),研究组治疗后乳杆菌、双歧杆菌、肠球菌均高于对照组(P<0.05),肠杆菌低于对照组(P<0.05)。2组治疗后DAO、D-乳酸、内毒素水平均较本组治疗前降低(P<0.05),且研究组治疗后均低于对照组(P<0.05)。2组治疗后血清TNF-α、IL-6、CRP水平均较本组治疗前降低(P<0.05),且研究组治疗后均低于对照组(P<0.05)。结论 中西医结合治疗小儿腹泻效果显著,能缩短病程,改善肠道环境和炎症因子,提高疗效,安全性高。
Objective To evaluate the effect of integrated medicine on intestinal microecological balance and inflammatory factor in infantile diarrhea.Methods Ninety-six cases of infantile diarrhea were assigned into the control group(n=48)and study group(n=48),in which they were treated with routine Western medicine and integrated medicine,respectively.The symptom recovery,traditional Chinese medicine(TCM)syndrome scores,intestinal flora,intestinal mucosal barrier function(diamine oxidase[DAO],D-lactic acid,endotoxin),inflammatory factor levels(tumor necrosis factorα[TNF-α],interleukin 6[IL-6],C-reactive protein[CRP])and clinical efficacy were compared between the two groups.Results The overall effective rate in the study group was significantly higher than that in the control group(95.83%[46/48]vs 77.08%[37/48],P<0.05).The recovery time was significantly shorter in the study group than in the control group(P<0.05).After treatment,TCM symptom scores in the both groups were significantly decreased(P<0.05),which were significantly decreased in the study group compared with the control group(P<0.05).Significantly increased Lactobacillus,Bifidobacterium and Enterococcus,and decreased Enterobacteriaceae were detected in the both groups(all P<0.05),and the study group was superior to the control group for Lactobacillus,Bifidobacterium,Enterococcus,and Enterobacteriaceae(all P<0.05).The levels of DAO,D-lactic acid,endotoxin in the both groups were significantly decreased(P<0.05),the decreases in the study group were more common than the control group(P<0.05).The levels of TNF-α,IL-6,CRP in the both groups were significantly decreased(P<0.05),the decreases in the study group were more prevalent compared with the control group(P<0.05).Conclusion The integrated medicine has a significant effect for treating infantile diarrhea,which can shorten the course of the disease,improve the intestinal environment and inflammatory factors,improve efficacy,and with a high safety.
作者
宋宇坤
郑淑玲
SONG Yukun;ZHENG Shuling(Department of Pediatrics,Beijing Daxing District Hospital of Integrated Chinese and Western Medicine,Beijing 102600)
出处
《河北中医》
2025年第8期1304-1308,共5页
Hebei Journal of Traditional Chinese Medicine
关键词
小儿腹泻
中西医结合疗法
肠道菌群
炎症因子
Infantile diarrhea
Integrated medicine treatment
Intestinal flora
Inflammatory factors
作者简介
宋宇坤(1990-),女,主治医师,硕士。从事儿科临床工作。
