摘要
目的探究他汀类药物及替罗非班治疗经皮桡动脉穿刺介入治疗(PTI)的冠心病的效果。方法将信丰县人民医院2023年3月-2024年5月收治的60例行PTI术的老年冠心病患者按照随机数字表法分为对照组30例和观察组30例。对照组单用阿托伐他汀治疗,观察组予以替罗非班联合阿托伐他汀治疗。比较两组临床治疗效果、血清炎症指标[血清白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)]水平、不良反应发生率。结果观察组治疗总有效率高于对照组(P<0.05)。与治疗前比较,两组治疗后血清炎症指标水平均降低(P<0.05),且与对照组比较,观察组血清炎症指标水平更低(P<0.05)。与对照组比较,观察组不良反应发生率更低(P<0.05)。结论替罗非班联合阿托伐他汀在老年冠心病患者PTI后的应用效果确切,能够降低患者血清炎症指标水平,且安全性较高。
Objective To explore the effect of statins and tirofiban in the treatment of coronary heart disease(CHD)with percutaneous transradial intervention(PTI).Methods A total of 60 elderly patients with coronary heart disease who underwent PTI in Xinfeng County People's Hospital from March 2023 to May 2024 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 30 patients in each group.The control group was treated with atorvastatin alone,and the observation group was treated with tirofiban combined with atorvastatin.The clinical treatment effect,serum inflammatory indexes[serum interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)]levels and incidence of adverse reactions(arrhythmia,heart failure,angina pectoris,cardiogenic shock)were compared between the two groups.Results The observation group had higher the total effective rate of treatment than that in the control group(P<0.05).Compared with before treatment,the levels of serum inflammatory indexes in both groups were decreased after treatment(P<0.05),and compared with the control group,the levels of serum inflammatory indexes in the observation group were lower(P<0.05).Compared with the control group,the incidence of adverse reactions in the observation group was lower(P<0.05).Conclusion Tirofiban combined with atorvastatin is effective in elderly patients with coronary heart disease after PTI,which can reduce the level of serum inflammatory markers and has high safety.
作者
刘平平
罗哲
林杰
LIU Pingping;LUO Zhe;LIN Jie(Department of Cardiovascular Medicine,Xinfeng County People's Hospital,Xinfeng 341600,Jiangxi,China)
出处
《医学信息》
2025年第16期131-134,共4页
Journal of Medical Information
基金
赣州市卫生健康委员会市级科研计划项目(编号:GZWJW202402325)。
关键词
冠心病
经皮桡动脉穿刺介入术
阿托伐他汀
替罗非班
Coronary heart disease
Percutaneous transradial intervention
Atorvastatin
Tirofiban
作者简介
刘平平(1989.5-),男,江西信丰县人,本科,主治医师,主要从事心血管内科临床工作。
