摘要
目的:观察马来酸曲美布汀胶囊联合小建中颗粒治疗腹泻型肠易激综合征的效果。方法:将我院2022年1月至2023年12月收治的86例腹泻型肠易激综合征患者随机分为对照组和观察组,每组43例。对照组患者采用马来酸曲美布汀胶囊治疗,观察组患者在对照组基础上联用小建中颗粒治疗,比较2组患者的疗效、症状评分、炎症因子水平以及不良反应发生情况。结果:观察组患者总有效率明显高于对照组(P<0.05)。治疗前2组患者症状评分比较差异无统计学意义(P>0.05);治疗后2组患者焦虑、肠鸣、大便时溏时泻、紧张、排便不尽感、食后腹胀、喜太息和食欲下降评分均明显降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前2组患者炎症因子水平比较差异无统计学意义(P>0.05);治疗后2组患者血清IL-1β、INF-γ、IL-6和TNF-α水平均明显降低(P<0.05),且观察组低于对照组(P<0.05)。2组患者皮疹、肝肾功能异常、恶心和失眠发生率比较差异无统计学意义(P>0.05)。结论:马来酸曲美布汀胶囊联合小建中颗粒对腹泻型肠易激综合征有显著的疗效,能明显减轻患者的临床症状,其机制可能与下调多种血清炎症介质水平有关。
Objective To observe the effect of trimebutine maleate capsules combined with Xiaojianzhong Granules in the treatment of diarrhea-predominant irritable bowel syndrome.Methods Total 86patients with diarrhea-predominant irritable bowel syndrome admitted to our hospital from January 2022to December 2023were randomly divided into a control group and an observation group,with 43cases in each group.Patients in the control group were treated with trimebutine maleate capsules,while patients in the observation group were treated with Xiaojianzhong granules on the basis of the control group.The efficacy,symptom scores,inflammatory factor levels and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).Before treatment,there was no significant difference in symptom scores between the two groups(P>0.05).After treatment,the scores of anxiety,borborygmus,loose stools,tension,incomplete defecation,postprandial abdominal distension,sighing and loss of appetite in both groups were significantly decreased(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference in the levels of inflammatory factors between the two groups(P>0.05).After treatment,the serum levels of IL-1β,INF-γ,IL-6 and TNF-αin both groups were significantly decreased(P<0.05),and the levels in the observation group were lower than those in the control group(P<0.05).Conclusion Trimebutine maleate capsules combined with Xiaojianzhong Granules have a significant effect on diarrhea-predominant irritable bowel syndrome,which can significantly alleviate the clinical symptoms of patients.The mechanism may be related to the down-regulation of the levels of various serum inflammatory mediators.
作者
杨琰琰
YANG Yan-yan(Department of Gastroenterology,Affiliated Hospital of Gansu Medical College,Pingliang,Gansu 744000)
出处
《中国肛肠病杂志》
2025年第7期62-65,共4页
Chinese Journal of Coloproctology
关键词
腹泻型肠易激综合征
马来酸曲美布汀胶囊
小建中颗粒
Diarrhea-predominant irritable bowel syndrome
Trimebutine maleate capsules
Xiaojianzhong granules
作者简介
第一作者:杨琰琰,女,甘肃平凉人,副主任医师,研究方向:溃疡性结肠炎、结直肠癌。E-mail:1131669487@qq.com。
