摘要
目的:观察糠酸莫米松鼻喷雾剂联合枸地氯雷他定治疗变应性鼻炎患者的效果。方法:选取2022年5月至2024年6月该院收治的60例变应性鼻炎患者进行前瞻性研究,采用抛硬币法将其分为对照组和观察组各30例。对照组采用枸地氯雷他定治疗,观察组在对照组基础上联合糠酸莫米松鼻喷雾剂治疗,比较两组治疗总有效率,临床症状改善时间,治疗前后血清炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]水平、通气功能指标[睡眠呼吸暂停低通气指数(AHI)、睡眠氧饱和度下降指数(ODI)、血氧饱和度(SpO_(2))]水平、鼻炎症状[鼻部症状总分分级标准(TNSS)]评分、生命质量[鼻结膜炎生存质量量表(RQLQ)]评分,以及不良反应发生率。结果:观察组治疗总有效率为96.67%(29/30),高于对照组的66.67%(20/30),差异有统计学意义(P<0.05);观察组鼻塞、喷嚏、流涕等临床症状改善时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组IL-6、TNF-α、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组AHI、ODI水平均低于对照组,SpO_(2)水平高于对照组,差异有统计学意义(P<0.05);治疗后,观察组TNSS和RQLQ评分均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:糠酸莫米松鼻喷雾剂联合枸地氯雷他定治疗变应性鼻炎患者可提高治疗总有效率,改善通气功能指标水平,缩短临床症状改善时间,降低炎性因子水平、鼻炎症状评分和生命质量评分,效果优于单纯枸地氯雷他定治疗。
Objective:To observe effects of Mometasone furoate aqueous nasal spray combined with Desloratadine citrate disodium in treatment of allergic rhinitis.Methods:A prospective study was conducted on 60 patients with allergic rhinitis admitted to the hospital from May 2022 to June 2024.They were divided into control group and observation group by using the coin tossing method,30 cases in each group.The control group was treated with Desloratadine citrate disodium,while the observation group was treated with Mometasone furoate aqueous nasal spray on the basis of that of the control group.The total effective rate of treatment,the improvement time of clinical symptoms,the levels of serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-ɑ(TNF-ɑ),hypersensitive C-reactive protein(hs-CRP)]and ventilation function indexes[sleep apnea hypopnea index(AHI),sleep oxygen saturation decline index(ODI),blood oxygen saturation(SpO_(2))],the rhinitis symptoms[total nasal symptoms score(TNSS)]score,the quality of life[rhinoconjunctivitis quality of life questionnaire(RQLQ)]score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.67%(29/30),which was higher than 66.67%(20/30)of the control group,and the difference was statistically significant(P<0.05).The improvement time of clinical symptoms such as nasal congestion,sneezing and runny nose in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-αand hs-CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of AHI and ODI in the observation group were lower than those in the control group,the level of SpO_(2) was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the scores of TNSS and RQLQ in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Mometasone furoate aqueous nasal spray combined with Desloratadine Citrate Disodium in the treatment of the patients with allergic rhinitis can improve the total effective rate of treatment,improve the levels of ventilation function indexes,shorten the improvement time of clinical symptoms,and reduce the levels of inflammatory factors,the rhinitis symptom scores and the quality of life scores.Moreover,it is superior to simple Desloratadine citrate disodium treatment.
作者
张艳飞
ZHANG Yanfei(Department of Otorhinolaryngology Head and Neck Surgery of Pingdingshan People’s Hospital No.1,Pingdingshan 467000 Henan,China)
出处
《中国民康医学》
2025年第15期45-48,共4页
Medical Journal of Chinese People’s Health
关键词
糠酸莫米松鼻喷雾剂
枸地氯雷他定
变应性鼻炎
炎性因子
通气功能
鼻炎症状
生命质量
Mometasone furoate aqueous nasal spray
Desloratadine citrate disodium
Allergic rhinitis
Inflammatory factor
Ventilation function
Rhinitis symptoms
Quality of life
作者简介
张艳飞(1989.02-),女,汉族,河南平顶山人,硕士研究生,主治医师,研究方向为耳鼻喉常见疾病的基础及临床治疗。
