摘要
目的:通过回顾性病例分析,系统评估清热止渴膏联合阿卡波糖治疗2型糖尿病(type 2 diabetes mellitus,T2DM)的临床疗效及安全性,重点探讨其对患者胰岛功能、糖代谢水平、脂质代谢相关参数的影响。方法:回顾性分析2021年2月—2022年12月在我院就诊的88例T2DM患者临床资料,按照标准筛选后根据治疗药物不同分成阿卡组(46例)、联合组(42例)。阿卡组予以阿卡波糖治疗,联合组予以清热止渴膏联合阿卡波糖治疗。比较两组糖代谢水平[空腹血糖(fasting blood glucose,FBG)、2 h血糖(2 h Blood glucose,PBG)、糖化血红蛋白(glycosylated hemoglobin,HbA_(1c))]、胰岛功能[空腹胰岛素(fasting insulin,INS)、胰岛素抵抗指数(HOMA-IR)、C-肽(CP)]、脂质代谢相关参数[总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(insulin resistance index,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)]、临床疗效;并采用Pearson相关性分析糖代谢水平与胰岛功能、脂质代谢相关参数的相关性。结果:治疗后,两组患者FBG、PBG、HbA1c水平明显低于治疗前,且联合组患者FBG、PBG、HbA1c水平低于阿卡组;两组患者CP较治疗前升高,INS、HOMA-IR较治疗前降低,联合组患者CP高于阿卡组,INS、HOMA-IR低于阿卡组;两组患者HDL-C较治疗前升高,TC、TG、LDL-C较治疗前降低,联合组HDL-C高于阿卡组,TC、TG、LDL-C低于阿卡组。联合组患者治疗总有效率高于阿卡组。Pearson相关性分析结果显示,FBG与INS、HOMA-IR、TG、LDL-C呈正相关,与HDL-C呈负相关;PBG与INS、HOMA-IR、TG、LDL-C呈正相关,与HDL-C呈负相关;HbA1c与HOMA-IR、TG呈正相关,与CP呈负相关。结论:清热止渴膏联合阿卡波糖治疗T2DM临床效果较好,尤其在改善糖代谢、恢复胰岛功能、调节脂质代谢方面效果突出,值得临床推广应用。
Objective To systematically evaluate the clinical efficacy and safety of Qingrezhike paste combined with acarbose in the treatment of type 2 diabetes mellitus(T2DM)by retrospective case analysis,focusing on its effects on islet function,glucose metabolism level and related parameters of lipid metabolism in patients.Methods The clinical data of 88 T2DM patients treated in our hospital from February 2021 to December 2022 were retrospectively analyzed,and they were divided into Acca group(46 cases)and combined group(42 cases)according to different therapeutic drugs after standard screening.The acca group was treated with acarbose,and the combined group was treated with Qingrezhike ointment combined with acarbose.The levels of glucose metabolism[fasting blood glucose(FBG),2 h Blood glucose(PBG),glycosylated hemoglobin(HbA1c)],islet function[fasting insulin(INS),insulin resistance index(HOMA-IR),C-peptide(CP)],lipid metabolism-related parameters[total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)LDL-C)],clinical efficacy;Pearson correlation was used to analyze the correlation between glucose metabolism and islet function and lipid metabolism.Results After treatment,the levels of FBG,PBG,and HbA1c in both groups of patients were significantly lower than before treatment,and the levels of FBG,PBG,and HbA1c in the combination group of glucose patients were lower than those in the Acao group.CP in two groups was higher than before treatment,INS and HOMA-IR were lower than before treatment,CP in combination group was higher than that in Acao group,INS and HOMA-IR were lower than that in Acao group.HDL-C in both groups was higher than before treatment,TC,TG and LDL-C were lower than before treatment,HDL-C in combination group was higher than Acca group,TC,TG and LDL-C were lower than Acca group.The total effective rate of combination group was higher than that of acca group.Pearson correlation analysis showed that FBG was positively correlated with INS,HOMA-IR,TG,LDL-C,and negatively correlated with HDL-C.PBG was positively correlated with INS,HOMA-IR,TG,LDL-C,and negatively correlated with HDL-C.HbA1c was positively correlated with HOMA-IR and TG,and negatively correlated with CP.Conclusion Qingrezhike paste combined with acarbose has good clinical effect in the treatment of T2DM,especially in improving glucose metabolism,restoring islet function and regulating lipid metabolism,which is worthy of clinical application.
作者
李蓓
应语
周华
LI Bei;YING Yu;ZHOU Hua(Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Provincial Hospital of Chinese Medicine,Nanjing 210029)
出处
《湖南师范大学学报(医学版)》
2025年第2期66-70,共5页
Journal of Hunan Normal University(Medical Sciences)
基金
江苏省中医院科技项目“清热止咳膏对糖尿病前期疾病转归及胰岛素β细胞功能的临床评价”(Y2021CX15)
作者简介
通信作者:周华,E-mail:526095099@qq.com
