摘要
目的探讨影响备孕夫妇生育储备功能的相关因素。方法选取孕前检查的备孕夫妇500对,对女性进行卵巢储备功能评估,对男性进行精子质量评估,根据抗米勒管激素(AMH)、窦卵泡数(AFC)水平将女性分为卵巢功能正常组和卵巢功能异常组,分析2组受试女性不同年龄段(<30岁、30~<35岁、35~<40岁、≥40岁)的卵巢储备功能,通过logistic回归分析法分析影响女性生育储备功能的风险因素;根据年龄精液质量将男性分为精液质量正常组和精液质量异常组,评估2组受试者男性的生育储备功能,并分析影响男性生育储备功能的风险因素。结果不同年龄组女性卵巢储备功能差异有统计学意义(P<0.05);年龄35~<40岁和年龄≥40岁的卵巢储备功能异常率为37%和79%。男性精液质量异常组人群占比为43%;影响男性精液质量异常的相关因素为身体质量指数(BMI)、慢性疾病史、吸烟史、饮酒史、生活工作压力(P<0.05);多因素分析结果显示,年龄、感染史、流产史、放射线和生活及工作压力是影响女性生育储备功能降低的独立危险因素(P<0.05)。结论年龄、感染史、流产史、放射线和生活及工作压力是女性卵巢功能的独立危险因素;BMI、慢性疾病史、吸烟史、饮酒史、生活工作压力是男性精液质量的影响因素。
Objective To investigate the factors which associated with reproductive reserve in couples preparing for pregnancy.Methods A total of 500 couples who underwent pre-pregnancy examinations were enrolled.Ovarian reserve function was assessed in women and sperm quality was evaluated in men,and screening analysis was performed to identify factors influencing reproductive reserve.Women were categorized into normal ovarian function group and abnormal ovarian function group based on the levels of anti-mullerian hormone(AMH)and sinus follicle count(AFC).Ovarian reserve function was compared across different age groups(<30 years,30~<35 years,35~<40 years,and≥40 years).Risk factors affecting female fertility reserve function were analyzed by logistic test.According to the semen quality of men,they were divided into the normal semen quality group and the abnormal semen quality group,and the fertility reserve function of the two groups was evaluated,and the risk factors affecting the fertility reserve function of men were analyzed.Results The difference in ovarian reserve function among women of different age groups was statistically significant(P<0.05),37%and 79%of women aged 35~<40 and≥40 years had abnormal ovarian reserve function.The percentage of men in the abnormal semen quality group was 43%.Factors associated with abnormal semen quality in men were body mass index(BMI),history of chronic diseases,smoking,alcohol consumption,and life/work stress(P<0.05).Multivariate analysis revealed that age,infection history,abortion history,radiation exposure,and life/work stress were independent risk factors for diminished female reproductive reserve(P<0.05).Conclusion Age,infection history,abortion history,radiation exposure,and life/work stress are independent risk factors for ovarian function in women,while BMI,chronic diseases,smoking,alcohol consumption,and life/work stress significantly influence semen quality in men.
作者
杨玉清
李旭丽
李伟娥
YANG Yuqing;LI Xuli;LI Weie(Yinchuan Maternal and Child Health Care Hospital,Yinchuan 750001,China)
出处
《宁夏医学杂志》
2025年第7期599-603,共5页
Ningxia Medical Journal
基金
银川市科学技术局社会支撑项目(2023SF26)。
关键词
备孕夫妇
生育储备功能
抗米勒管激素
精液质量
影响因素
Couples preparing for pregnancy
Reproductive reserve function
AMH
Semen quality
Influence factor
作者简介
杨玉清(1977-),女,大学本科,副主任医师,主要从事婚前、孕前优生优育咨询及生殖保健等研究。
