摘要
目的:分析血浆D-二聚体(D-D)、血小板计数(PLT)、红细胞分布宽度与淋巴细胞比值(RLR)水平联合检测对肝硬化患者发生食管胃底静脉曲张破裂出血(EVB)的预测价值。方法:回顾性分析2020—2023年该院收治的295例肝硬化患者的临床资料,根据是否发生EVB将其分为EVB组(n=102)与非EVB组(n=193)。比较两组、不同食管静脉曲张严重程度EVB患者血浆D-D、PLT、RLR水平,绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),分析血浆D-D、PLT、RLR水平单项及联合检测对肝硬化患者发生EVB的预测价值。结果:EVB组血浆D-D、RLR水平均高于非EVB组,PLT水平低于非EVB组,差异有统计学意义(P<0.05);重度、中度EVB患者血浆D-D、RLR水平均高于轻度患者,且重度患者高于中度患者,重度、中度EVB患者PLT水平均低于轻度患者,且重度患者低于中度患者,差异有统计学意义(P<0.05);ROC曲线分析结果显示,血浆D-D、PLT、RLR水平单项及联合检测预测肝硬化患者发生EVB的AUC分别为0.771、0.754、0.798、0.925,其中联合检测的AUC最高。结论:血浆D-D、PLT、RLR水平联合检测对肝硬化患者发生EVB的预测价值高于各指标单项检测。
Objective:To analyze predictive value of combined detection of plasma D-dimer(D-D),platelet count(PLT),red blood cell distribution width to lymphocyte ratio(RLR)levels for esophageal and gastric variceal bleeding(EVB)in patients with liver cirrhosis.Methods:The clinical data of 295 patients with liver cirrhosis admitted to the hospital from 2020 to 2023 were retrospectively analyzed.According to the occurrence of EVB,they were divided into EVB group(n=102)and non-EVB group(n=193).The levels of plasma D-D,PLT and RLR were compared between the two groups and among the EVB patients with different severity of esophageal varices.The receiver operating characteristic(ROC)curve was drawn and the area under the curve(AUC)was calculated.The predictive value of single and combined detection of plasma D-D,PLT and RLR levels for EVB in the patients with liver cirrhosis were analyzed.Results:The levels of plasma D-D and RLR in the EVB group were higher than those in the non-EVB group,the PLT level was lower than that in the non-EVB group,and the differences were statistically significant(P<0.05).The levels of plasma D-D and RLR in patients with the severe and moderate EVB were higher than those in the mild patients,and those in the severe patients were higher than those in the moderate patients;the PLT levels of the patients with severe and moderate EVB were lower than those of the mild patients,and that of the severe patients was lower than that of the moderate patients;and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the AUC of single and combined detection of plasma D-D,PLT and RLR levels in the prediction of EVB in the patients with cirrhosis were 0.771,0.754,0.798 and 0.925,separately,and the AUC of combined detection was the highest.Conclusions:The predictive value of combined detection of the plasma D-D,PLT and RLR levels for EVB in the patients with liver cirrhosis is higher than that of single detection of each index.
作者
李真真
李宁
LI Zhenzhen;LI Ning(Department of Clinical Laboratory of the General Hospital of Jinshui District,Zhengzhou 450000 Henan,China)
出处
《中国民康医学》
2025年第14期133-135,共3页
Medical Journal of Chinese People’s Health
作者简介
李真真(1984.08-),女,回族,河南郑州人,本科,主管检验师,研究方向为肝硬化临床检验。
