摘要
目的:观察阿司匹林联合硫酸镁与拉贝洛尔治疗子痫前期患者的效果。方法:回顾性分析2021年1月至2024年3月该院收治的94例子痫前期患者的临床资料,按治疗方法不同将其分成研究组(n=47)与对照组(n=47)。对照组给予硫酸镁联合拉贝洛尔治疗,研究组在对照组基础上联合阿司匹林治疗,比较两组临床疗效,治疗前后血压(收缩压、舒张压)、血管内皮功能指标[超氧化物歧化酶(SOD)、内皮素-1(ET-1)]水平,不良反应发生率,以及不良妊娠结局发生率。结果:研究组治疗总有效率为95.74%,高于对照组的80.85%,差异有统计学意义(P<0.05);治疗后,两组收缩压、舒张压水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组ET-1水平均低于治疗前,且研究组低于对照组,两组SOD水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);研究组不良妊娠结局发生率为2.13%,低于对照组的17.02%,差异有统计学意义(P<0.05)。结论:阿司匹林联合硫酸镁与拉贝洛尔治疗子痫前期患者可提高治疗总有效率,改善血管内皮功能指标水平,以及降低血压水平和不良妊娠结局发生率的效果优于硫酸镁联合拉贝洛尔治疗。
Objective:To observe effects of Aspirin combined with Magnesium sulfate and Labetalol in treatment of patients with preeclampsia.Methods:The clinical data of 94 patients with preeclampsia admitted to this hospital from January 2021 to March 2024 were retrospectively analyzed.According to different treatment methods,they were divided into study group(n=47)and control group(n=47).The control group was treated with Magnesium sulfate combined with Labetalol,while the study group was treated with Aspirin on the basis of those of the control group.The clinical efficacy,the levels of blood pressure(systolic blood pressure,diastolic blood pressure)and vascular endothelial function indexes[superoxide dismutase(SOD),endothelin-1(ET-1)]before and after the treatment,the incidence of adverse reactions,and the incidence of adverse pregnancy outcomes were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.74%,which was higher than 80.85%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of systolic blood pressure and diastolic blood pressure in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of ET-1 in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;the level of SOD in the two groups was higher than that before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The incidence of adverse pregnancy outcomes in the study group was 2.13%,which was lower than 17.02%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Aspirin combined with Magnesium sulfate and Labetalol in the treatment of the preeclampsia patients can improve the total effective rate of treatment,improve the levels of vascular endothelial function indexes,and reduce the levels of blood pressure and the incidence of adverse pregnancy outcomes.Moreover,it is superior to Magnesium sulfate combined with Labetalol treatment.
作者
刘晶晶
Liu Jingjing(Department of Obstetrics and Gynecology of Zhengzhou West Area Hospital of TCM,Zhengzhou 450000 Henan,China)
出处
《中国民康医学》
2025年第14期61-64,共4页
Medical Journal of Chinese People’s Health
关键词
阿司匹林
硫酸镁
拉贝洛尔
子痫前期
血压
血管内皮功能
妊娠结局
Aspirin
Magnesium sulfate
Labetalol
Preeclampsia
Blood pressure
Vascular endothelial function
Pregnancy outcome
作者简介
刘晶晶(1985.11-),女,汉族,河南驻马店人,本科,主治医师,研究方向为妊娠高血压的临床研究。
