摘要
目的探究硝苯地平联合硫酸镁在妊娠期高血压患者中的应用效果.方法选取我院于2020年6月—2022年3月收治的76例妊娠期高血压患者为研究对象,采用随机数字表法分为观察组(n=38)和对照组(n=38).两组患者入院后均接受饮食调护、吸氧等常规治疗,对照组在常规治疗基础上采用静脉滴注硫酸镁治疗,观察组在对照组基础上联合采用口服硝苯地平治疗.对比两组患者临床疗效、血压水平、肾脏血流动力学指标以及不良妊娠结局.结果观察组临床总有效率高于对照组,差异有统计学意义(P<0.05).与对照组对比,观察组治疗后收缩压和舒张压水平均较低,组间差异有统计学意义(P<0.05).与对照组相比,观察组治疗后阻力指数、收缩期峰值流速(PSV)/舒张末期峰值流速(EDV)、搏动指数均更低,PSV、EDV均较快,组间差异有统计学意义(P<0.05).观察组不良妊娠结局发生率较对照组低,差异有统计学意义(P<0.05).结论妊娠期高血压患者采用硝苯地平联合硫酸镁治疗,有利于提高患者的治疗效果,能够有效控制患者的血压水平,改善其肾脏血流动力学指标,且不良妊娠结局较少,值得临床进一步推广.
Objective To investigate the effect of nifedipine combined with magnesium sulfate in patients with pregnancy induced hypertension.Methods 76 patients with pregnancy induced hypertension admitted to the hospital from June 2020 to March 2022 were selected as the study objects,and were divided into an observation group(n=38)and a control group(n=38)by random number table method.After admission,the patients in both groups received routine treatment such as diet care and oxygen inhalation.The control group was treated with magnesium sulfate by pulse drip on the basis of routine treatment,and the observation group was treated with nifedipine orally on the basis of the control group.The clinical efficacy,blood pressure level,renal hemodynamic indexes and adverse pregnancy outcomes were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,with a statistical difference(P<0.05).Compared with the control group,the levels of systolic blood pressure and diastolic blood pressure in the observation group were lower after treatment,and the differences between the groups were statistically significant(P<0.05).Compared with the control group,the resistance index,peak systolic velocity(PSV)/peak end diastolic velocity(EDV)and pulsatility index in the observation group were lower after treatment,the PSV and EDV in the observation group were faster,and the differences between the groups were statistically significant(P<0.05).The incidence of adverse pregnancy outcome in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of nifedipine and magnesium sulfate for the treatment of patients with pregnancy induced hypertension is beneficial to improve the therapeutic effect of the patients,can effectively control the blood pressure level of the patients,improve the renal hemodynamic indexes,and have fewer adverse pregnancy outcomes,which is worthy of further clinical promotion.
作者
孙玉婷
刘世双
SUN Yuting;LIU Shishuang(Department of Obstetrics,Ju County Hospital of Traditional Chinese Medicine,Rizhao Shandong,276500,China)
出处
《反射疗法与康复医学》
2022年第21期175-178,共4页
Reflexology And Rehabilitation Medicine
关键词
妊娠期高血压
硝苯地平
硫酸镁
临床疗效
血压
血流动力学指标
妊娠结局
Pregnancy induced hypertension
Nifedipine
Magnesium sulphate
Clinical efficacy
Blood pressure
Hemodynamic indexes
Pregnancy outcome
作者简介
孙玉婷(1978-),女,山东莒县人,本科,主治医师,研究方向:妇女妊娠、分娩、产褥期疾病诊疗.
