摘要
目的 通过对住院2型糖尿病(T2DM)合并代谢相关脂肪性肝病(MAFLD)患者临床特征与血尿酸(SUA)相关性研究,探讨SUA与T2DM合并MAFLD的相关性。方法 选取秦皇岛市第一医院内分泌科住院的285例T2DM合并MAFLD患者为研究对象,依据MAFLD的严重程度分为4组(无MAFLD组、轻度MAFLD组、中度MAFLD组、重度MAFLD组);按照SUA基线水平四分位分为4组(Q1、Q2、Q3、Q4)。检测受试者空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、SUA、肌酐(Cr)等生物化学指标和影像学检查结果。比较各组MAFLD的检出率,logistics回归分析基线SUA水平对新发MAFLD的影响。结果 男性T2DM患者更容易合并MAFLD,且年龄越小、病程越短、男性更容易合并重度MAFLD。随着MAFLD严重程度的增加,BMI、SUA水平增加。重度MAFLD患者的舒张压、TG、TC、LDL-C、FPG、FINS水平高于无或轻或中度MAFLD组患者,差异有统计学意义(P<0.05)。随着SUA水平的增加,MAFLD所占比例增加。在四分位数血尿酸水平中,年龄、性别、舒张压、BMI、Cr、FINS等差异有统计学意义(P<0.05)。Logistic回归分析显示,随着SUA水平的升高,MAFLD发生风险亦随之升高,且SUA水平是MAFLD发病的独立危险因素。结论 SUA增高是MAFLD发病的独立危险因素,可作为评估MAFLD发生风险的指标。
Objective To illustrate the correlation of serum uric acid(SUA)with type 2 diabetes mellitus(T2DM)combined with metabolic dysfunction-associated steatotic liver disease(MAFLD)by analyzing the clinical features correlated with SUA in hospitalized T2DM patients with MAFLD.Methods A total of 285 T2DM combined with MAFLD patients hospitalized in the Endocrinology Department of the First Hospital of Qinhuangdao were selected.They were divided into 4 groups(no MAFLD,mild MAFLD,moderate MAFLD,and severe MAFLD)according to MAFLD severity.They were also divided into Q1-Q4 groups according to the quartile of baseline SUA.Fasting blood glucose(FPG),triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol l(LDL-C),SUA,creatinine(Cr)and imaging results were recorded.The detection rate of MAFLD in each group was calculated.Logistics regression was performed to analyze the effect of baseline SUA levels on new-onset MAFLD in T2DM patients.Results Male T2DM patients were more likely to have MAFLD,and T2DM patients with younger age,shorter disease duration,and men were more likely to have severe MAFLD.As the severity of MAFLD increased,body mass index(BMI)and SUA levels increased.Diastolic blood pressure(DBP),TG,TC,LDL-c,FPG,and faster insulin(FINS)were significantly higher in the severe MAFLD group than the no MAFLD,mild MAFLD,and moderate MAFLD groups(P<0.05).The proportion of MAFLD increased as the SUA levels increased.Among the quartile blood uric acid levels,age,sex,diastolic blood pressure,BMI,Cr,and FINS were significantly different(P<0.05).Logistic regression analysis showed that the level of SUA increased the risk of MAFLD,and SUA level was an independent risk factor for the onset of MAFLD.Conclusion Increased SUA is an independent risk factor for the onset of MAFLD and can be used as an indicator to assess the risk of developing MAFLD.
作者
王鲲
贾晓娇
牛紫如
陆强
谢长顺
WANG Kun;JIA Xiaojiao;NIU Ziru(First Hospital of Qinhuangdao,Hebei,Qinhuangdao 066000,China)
出处
《河北医药》
2025年第7期1104-1108,共5页
Hebei Medical Journal
基金
秦皇岛市科技计划项目(编号:202401A103)。
关键词
2型糖尿病
代谢相关脂肪性肝病
尿酸
type 2 diabetes mellitus
metabolic-related fatty liver diseases
blood uric acid
作者简介
通信作者:谢长顺15512221629@163.com。
