摘要
目的:探讨镇肝熄风汤在肝火亢盛证子痫前期(PE)产妇治疗中的应用价值及对血压、血流动力学及血清指标的影响。方法:采取前瞻性研究,选择2022年4月—2024年4月于郑州市第一人民医院接受治疗的80例PE产妇,按随机数字表法分为对照组和观察组,各40例。对照组给予拉贝洛尔治疗,观察组在对照组基础上加用镇肝熄风汤治疗。两组患者均连续治疗至终止妊娠。于治疗7 d时,比较两组临床疗效。比较两组不同时点(治疗前、治疗3 d、7 d)血压[收缩压(SBP)、舒张压(DBP)]控制水平。比较两组治疗前、治疗7 d时,两组血流动力学[心输出量(CO)、心脏指数(CI)]指标、钙镁离子、氧化应激[过氧化氢酶(CAT)、脂过氧化物(LPO)]及炎症因子[肿瘤坏死因子-ɑ(TNF-ɑ)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平。统计并比较两组不良妊娠结局及不良反应发生情况。结果:治疗3 d、7 d时,两组SBP、DBP低于治疗前(P<0.05),治疗7 d时低于治疗3 d时(P<0.05),观察组治疗3 d、7 d时,SBP、DBP低于对照组(P<0.05);治疗7 d,两组CO、CI低于治疗前(P<0.05),观察组低于对照组(P<0.05);治疗7 d,两组CAT水平高于治疗前(P<0.05),LPO、TNF-ɑ、IL-6、CRP水平低于治疗前(P<0.05),观察组CAT水平高于对照组(P<0.05),LPO、TNF-ɑ、IL-6、CRP水平低于对照组(P<0.05);观察组总不良妊娠结局发生率低于对照组(P<0.05)。结论:镇肝熄风汤能够有效稳定PE产妇血压水平,缓解机体氧化应激、炎症反应及血流动力学,降低不良妊娠结局风险。
Objective:To investigate the therapeutic value of Zhengan Xifeng Decoction in preeclampsia(PE)patients with liver-fire hyperactivity syndrome and its effects on blood pressure,hemodynamics and serum indicators.Methods:In this prospective study,80 PE patients treated at Zhengzhou First People's Hospital from April 2022 to April 2024 were randomly divided into control group and observation group,with 40 patients in each group.The control group received labetalol treatment,while the observation group received the same plus Zhengan Xifeng Decoction.Both groups continued treatment until termination of pregnancy.Clinical efficacy was evaluated after 7 days of treatment.Blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)]was measured at baseline,3 days and 7 days of treatment.Hemodynamics[cardiac output(CO),cardiac index(CI)],calcium/magnesium ions,oxidative stress[catalase(CAT),lipid peroxide(LPO)]and inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)]were compared before and after 7 days of treatment.Adverse pregnancy outcomes and adverse reactions were recorded.Results:At 3 and 7 days of treatment,both groups showed lower SBP and DBP compared to baseline(P<0.05),with greater reductions in the observation group(P<0.05).After 7 days,CO and CI decreased in both groups(P<0.05),with lower values in the observation group(P<0.05).CAT levels increased(P<0.05)while LPO,TNF-α,IL-6 and CRP decreased(P<0.05)in both groups after treatment,with more significant changes in the observation group(P<0.05).The observation group had lower incidence of adverse pregnancy outcomes(P<0.05).Conclusion:Zhengan Xifeng Decoction effectively stabilizes blood pressure,alleviates oxidative stress,inflammation and hemodynamic abnormalities,and reduces risks of adverse pregnancy outcomes in PE patients.
作者
田春玲
李晓茹
刘舒鑫
TIAN Chunling;LI Xiaoru;LIU Shuxin(Department of Obstetrics and Gynecology,Zhengzhou First People's Hospital,Zhengzhou 450008,China)
出处
《中医药学报》
2025年第8期94-98,共5页
Acta Chinese Medicine and Pharmacology
基金
河南省中医药科学研究专项课题(2019ZY2065)。
关键词
子痫前期
拉贝洛尔
镇肝熄风汤
血压
Preeclampsia
Labetalol
Zhengan Xifeng Decoction
Blood pressure
作者简介
田春玲(1981-),女,硕士,副主任医师,研究方向:中医妇科学。
