摘要
目的分析缺氧诱导因子-1α(HIF-1α)、肾损伤因子-1(KIM-1)在IgA血管炎(IgAV)患儿中的表达及其预测肾损伤发生的价值。方法选取2023年1月至2024年12月在周口市妇幼保健院就诊的118例IgAV患儿为研究对象,根据其是否合并肾损伤分为对照组(未合并肾损伤,n=78)和观察组(合并肾损伤,n=40)。比较两组患儿HIF-1α、KIM-1以及血清肌酐(Scr)、尿素氮(BUN)、尿酸(UA)水平;使用Pearson相关性分析法分析HIF-1α、KIM-1与Scr、BUN、UA的相关性;使用受试者工作特征(ROC)曲线分析HIF-1α、KIM-1水平预测患儿发生肾损伤的临床价值。结果观察组HIF-1α、KIM-1、Scr、BUN及UA水平均高于对照组(P<0.001);Pearson相关性分析结果显示,患儿HIF-1α、KIM-1与Scr、BUN、UA水平均呈正相关(P<0.001);ROC曲线分析结果显示,HIF-1α水平预测患儿发生肾损伤的最佳临界值为27.80 pg/mL,此时曲线下面积为0.921(95%CI:0.855~0.987,P<0.001),灵敏度为87.50%,特异度为88.46%;KIM-1水平预测患儿发生肾损伤的最佳临界值为1.85 ng/mL,此时曲线下面积为0.949(95%CI:0.897~1.000,P<0.001),灵敏度为90.00%,特异度为96.15%。结论HIF-1α、KIM-1在IgAV伴肾损伤患儿中呈高表达,且HIF-1α、KIM-1水平与患儿肾损伤程度呈正相关,检测HIF-1α、KIM-1水平在预测患儿发生肾损伤中具有较高临床价值。
Objective To analyze the expression of hypoxia-inducible factor-1α(HIF-1α)and kidney injury molecule-1(KIM-1)in children with IgA vasculitis(IgAV)and its value in predicting kidney injury.Methods A total of 118 children with IgAV treated in our hospi-tal from January 2023 to December 2024 were enrolled in the study.According to the presence or absence of kidney injury,they were divided into the control group(without kidney injury,n=78)and the observation group(with kidney injury,n=40).The levels of HIF-1α,KIM-1,serum creatinine(Scr),blood urea nitrogen(BUN),and uric acid(UA)were compared between the two groups.Pearson correlation analysis was used to analyze the correlation between HIF-1α,KIM-1 levels and Scr,BUN,UA levels.The receiver operating characteristic(ROC)curve was used to analyze the clinical value of HIF-1αand KIM-1 levels in predicting the occurrence of kidney injury in children with IgAV.Results The lev-els of HIF-1α,KIM-1,Scr,BUN,and UA in the observation group were all higher than those in the control group(P<0.001).Pearson correla-tion analysis showed that HIF-1α,KIM-1 levels were all positively correlated with Scr,BUN,and UA levels in children with IgAV(P<0.001).ROC curve analysis showed that the best critical value of HIF-1αlevel for predicting kidney injury in children with IgAV was 27.80 pg/mL,the area under the curve at this time was 0.921(95%CI:0.855~0.987,P<0.001),the sensitivity was 87.50%,and the specificity was 88.46%.The best critical value of KIM-1 level for predicting kidney injury in children with IgAV was 1.85 ng/mL,the area under the curve at this time was 0.949(95%CI:0.897~1.000,P<0.001),the sensitivity was 90.00%,and the specificity was 96.15%.Conclusion The HIF-1αand KIM-1 are highly expressed in children with IgAV with kidney injury,the levels of HIF-1αand KIM-1 are positively correlated with the de-gree of kidney injury of the children with IgAV,and the detection of HIF-1αand KIM-1 levels in children with IgAV has high clinical value in predicting the occurrence of kidney injury.
作者
李平
王芳
史洋洋
王柯岩
LI Ping;WANG Fang;SHI Yangyang;WANG Keyan(Department of Pediatrics,Zhoukou Maternal and Child Health Hospital(Zhoukou Children's Hospital),Zhoukou 466000,China)
出处
《安徽医学》
2025年第7期853-857,共5页
Anhui Medical Journal
