摘要
钙调磷酸酶B蛋白(calcineurin B like protein, CBL)互作蛋白激酶(CBL-interacting protein kinase,CIPK)是一类Ser/Thr蛋白激酶,在植物生长发育和逆境胁迫响应过程中发挥重要作用。CIPK可自磷酸化或靶向磷酸化其他信号因子以响应生物和非生物逆境胁迫,也可参与脱落酸(abscisic acid,ABA)、赤霉素(gibberellic acid, GA)、乙烯(ethylene, ETH)、水杨酸(salicylic acid, SA)等植物激素信号通路来调节植物生长发育过程。此外,CIPK通过与CBL蛋白特异性互作形成复合物对盐碱、干旱、极端低温及重金属等逆境胁迫做出应答反应。本文对植物CIPKs的发现、结构、分类、调控机制及其在逆境胁迫响应中的作用等方面研究成果进行综述,并对其未来研究方向进行展望,为农作物抗逆性遗传改良和生物育种提供了参考。
Calcineurin B-like protein(CBL)-interacting protein kinases(CIPKs)are a group of Ser/Thr protein kinases,playing a crucial role in the growth,development,and stress responses of plants.CIPKs can undergo autophosphorylation or target the phosphorylation of other signaling factors in responses to biotic and abiotic stresses.In addition,they are involved in the signaling pathways of plant hormones such as abscisic acid (ABA), gibberellic acid (GA), ethylene (ETH), and salicylic acid (SA) to regulate plant growth and development. Furthermore, CIPKs respond to stresses such as salinity, drought, cold, and heavy metals by forming complexes through specific interactions with CBLs. In this study, we summarized the discovery, structures, classification, regulatory mechanisms, and roles of CIPKs in plant responses to stresses and made an outlook on the future research directions. This review is expected to provide genetic resources and theoretical foundations for the genetic improvement and breeding of crops with stress tolerance.
作者
杨冰姿
伍国强
魏明
成斌
YANG Bingzi;WU Guoqiang;WEI Ming;CHENG Bin(School of Life Science and Engineering,Lanzhou University of Technology,Lanzhou 730050,Gansu,China)
出处
《生物工程学报》
北大核心
2025年第7期2596-2609,共14页
Chinese Journal of Biotechnology
基金
国家自然科学基金(32360483,32160466)
甘肃省自然科学基金重点项目(23JRRA764)
甘肃省省级生态文明建设重点研发专项(25YFFA011)。
关键词
钙调磷酸酶B蛋白互作蛋白激酶
CBL-CIPK复合物
磷酸化
蛋白互作
抗逆境性
calcineurin B-like protein(CBL)-interacting protein kinase(CIPK)
CBL-CIPK complex
phosphorylation
protein-protein interaction
stress tolerance
作者简介
Corresponding author:伍国强.E-mail:gqwu@lut.edu.cn。
