摘要
肝脏疾病早期不易被发现,有创性诊断方式如肝穿刺虽然诊断相对准确,但接受度不高,严重制约肝脏疾病诊疗技术的提高,因此寻找新的生物标志物及新的治疗靶点尤为重要。转运RNA衍生小RNA(tsRNA)作为新兴的液体活检生物标志物,在病毒性肝炎、脂肪性肝病、肝损伤、肝癌等肝脏疾病中异常表达,通过发挥调节基因表达、表观遗传调控、蛋白质翻译等生物学功能,影响肝脏疾病的发生和进展。本文就tsRNA的来源和分类、生物学功能以及tsRNA作为肝脏疾病生物标志物和潜在治疗靶点进行综述,以期为肝脏疾病的早期诊断及治疗提供思路。
Liver diseases cannot be easily detected in the early stage,and although invasive diagnostic methods,such as liver biopsy,are relatively accurate,they tend to have a low degree of acceptance,which greatly limits the improvement in diagnosis and treatment techniques for liver diseases.Therefore,it is of great importance to search for new biomarkers and therapeutic targets.As an emerging biomarker for liquid biopsy,tRNA-derived small RNA(tsRNA)is abnormally expressed in various liver diseases including viral hepatitis,fatty liver disease,liver injury,and liver cancer,and it can affect the development and progression of liver diseases by regulating the biological functions such as gene expression,epigenetic regulation,and protein translation.This article reviews the origin,classification,and biological function of tsRNA,as well as the research advances in tsRNA as biomarkers and potential therapeutic targets for liver diseases,so as to provide ideas for the early diagnosis and treatment of liver diseases.
作者
李银丽
徐炎
管志伟
孟璐
渠怡彤
邱建利
LI Yinli;XU Yan;GUAN Zhiwei;MENG Lu;QU Yitong;QIU Jianli(Children’s Hospital,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;School of Pediatrics,Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《临床肝胆病杂志》
北大核心
2025年第6期1227-1234,共8页
Journal of Clinical Hepatology
基金
国家自然科学基金(81804142,82474570)
中国博士后科学基金面上项目(2023M731027)。
作者简介
通信作者:邱建利,qiujianli@126.com(ORCID:0000-0001-6796-3774)。
