摘要
目的:探讨冠心病心绞痛患者采用麝香通心滴丸联合尼可地尔进行治疗,对其心绞痛发作情况及心功能的影响。方法:回顾性分析沈阳医学院附属中心医院2022年1月—2023年12月收治的80例冠心病心绞痛患者的临床资料,根据治疗方式的不同分为两组。对照组(n=40)采用尼可地尔治疗,试验组(n=40)在对照组基础上加用麝香通心滴丸治疗。比较两组临床疗效、心绞痛发作情况及心功能指标,统计两组不良反应发生率。结果:相较于对照组,试验组总有效率显著高,差异有统计学意义(P<0.05)。相较于对照组,试验组治疗后心绞痛发作频率显著少,每次持续时间显著短,S-T段变化情况显著优,差异均有统计学意义(P<0.05)。相较于对照组,试验组治疗后左心室射血分数(LVEF)、每搏输出量(SV)均显著高,左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)均显著低,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:针对冠心病心绞痛患者,采用麝香通心滴丸联合尼可地尔的联合治疗方案,可有效减少心绞痛发作频率,缩短心绞痛发作时长,促进患者心功能指标恢复,且安全性较高。
Objective:To investigate the effects of using Shexiang Tongxin Dripping Pills combined with Nicorandil on the incidence of angina pectoris and cardiac function in patients with coronary heart disease and angina pectoris.Method:A retrospective analysis was conducted on the clinical data of 80 patients with coronary heart disease and angina pectoris admitted to the Shenyang Medical College Affiliated Central Hospital from January 2022 to December 2023.According to different treatment methods,they were divided into two groups.The control group(n=40)was treated with Nicorandil,and the experimental group(n=40)was treated with Shexiang Tongxin Dropping Pills in addition to Nicorandil on the basis of the treatment of the control group.The clinical efficacy,episodes of angina pectoris,and cardiac function indicators between two groups were compared,and the incidence of adverse reactions between the two groups was counted.Result:Compared with the control group,the total effective rate of the experimental group was significantly higher,the difference was statistically significant(P<0.05).Compared with the control group,the experimental group had significantly fewer frequency and shorter duration of angina pectoris after treatment,and showed significantly better changes in the S-T segment,the differences were statistically significant(P<0.05).Compared with the control group,the experimental group had significantly higher left ventricular ejection fraction(LVEF)and stroke volume(SV)after treatment,and significantly lower left ventricular end systolic diameter(LVESD)and left ventricular end diastolic diameter(LVEDD),the differences were statistically significant(P<0.05).Comparison of the incidence of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion:For patients with coronary heart disease and angina pectoris,the combination therapy of Shexiang Tongxin Dripping Pills and Nicorandil can effectively reduce the frequency of angina pectoris,shorten the duration of angina pectoris,promote the recovery of patients'cardiac function indicators,and has high safety.
作者
李婧
孙奡燕
温春琪
LI Jing;SUN Aoyan;WEN Chunqi(Department of Cardiovascular Medicine,Shenyang Medical College Affiliated Central Hospital,Shenyang 110000,China;不详)
出处
《中国医学创新》
2025年第16期81-85,共5页
Medical Innovation of China
基金
国家卫生健康委“十四五”规划全国重点课题(YYWS5910)。
关键词
冠心病
心绞痛
麝香通心滴丸
尼可地尔
心功能
Coronary heart disease
Angina pectoris
Shexiang Tongxin Dripping Pills
Nicorandil
Heart function
作者简介
通信作者:李婧。
