摘要
目的:观察益生菌制剂联合多奈哌齐在轻中度认知障碍伴衰弱患者中的疗效。方法:选取2022年1月—2024年1月上饶市人民医院收治的80例轻中度认知障碍伴衰弱的阿尔茨海默病(AD)患者,按随机数字表法分为研究组和对照组,各40例。两组均予以营养支持,对照组采用多奈哌齐治疗,研究组在对照组基础上联合益生菌制剂治疗。评估两组的临床疗效及治疗前、治疗6个月后简易精神状态检查量表(MMSE)评分、Barthel指数、前白蛋白(PA)、转铁蛋白(TRF)、白蛋白(ALB)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、血清神经丝轻链蛋白(Nf-L)和神经元特异性烯醇化酶(NSE)指标水平。结果:治疗6个月后,两组MMSE评分、Barthel指数均高于治疗前,且研究组MMSE评分高于对照组,差异均有统计学意义(P<0.05);但两组Barthel指数比较,差异无统计学意义(P>0.05)。研究组临床疗效高于对照组(P<0.05)。治疗6个月后,两组PA、TRF、ALB水平均高于治疗前,且研究组均高于对照组(P<0.05),两组IL-6、hs-CRP、Nf-L、NSE指标水平均低于治疗前,且研究组均低于对照组(P<0.05)。结论:益生菌制剂联合多奈哌齐可以提升轻中度认知障碍伴衰弱的AD患者的认知水平和生活活动能力,改善患者的营养状态及血清神经炎症指标和神经元损伤指标。
Objective:To observe the efficacy of probiotic preparation combined with Donepezil in patients with mild-moderate cognitive impairment and frailty.Method:A total of 80 patients with mild-moderate cognitive impairment and frailty Alzheimer's disease(AD)treated in Shangrao People's Hospital from January 2022 to January 2024 were selected and divided into study group and control group according to random number table method,with 40 cases in each group.Both groups were given nutritional support,the control group was treated with Donepezil,and the study group was treated with probiotic preparation based on the control group.The clinical efficacy,the score of mini-mental state examination(MMSE),Barthel index,prealbumin(PA),transferrin(TRF),albumin(ALB),interleukin-6(IL-6),hypersensitive C reactive protein(hs-CRP)and serum neurofilament light chain protein(Nf-L)and neuron-specific enolase(NSE)levels were evaluated in both groups before treatment and 6 months after treatment.Result:After 6 months of treatment,MMSE score and Barthel index in two groups were higher than those before treatment,and MMSE score in study group was higher than that in control group,the differences were statistically significant(P<0.05);there was no significant difference in Barthel index between the two groups(P>0.05).The clinical effect of the study group was higher than that of the control group(P<0.05).After 6 months of treatment,the levels of PA,TRF and ALB in two groups were higher than those before treatment,and those in the study group were higher than those in the control group(P<0.05).The levels of IL-6,hs-CRP,Nf-L and NSE in both groups were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).Conclusion:Probiotic preparation combined with Donepezil can improve the cognitive level and living activity ability of AD patients with mild-moderate cognitive impairment and frailty,and improve the nutritional status,serum neuroinflammatory indexes and neuronal injury indexes of patients.
作者
余义丰
阮雯静
周准
YU Yifeng;RUAN Wenjing;ZHOU Zhun(Department of General Medicine,Shangrao People's Hospital,Shangrao 334000,China;不详)
出处
《中国医学创新》
2025年第16期22-26,共5页
Medical Innovation of China
关键词
轻中度认知障碍
衰弱
多奈哌齐
益生菌制剂
Mild-moderate cognitive impairment
Frailty
Donepezil
Probiotic preparation
作者简介
通信作者:阮雯静。
