摘要
结肠癌的转移机制主要包括肿瘤细胞上皮-间质转化(EMT)、肿瘤微环境变化、肠道菌群失调及多种分子通路异常激活等,其中EMT在转移中起关键作用。目前,临床治疗多采用个体化策略,治疗方法包括手术治疗、化疗、靶向治疗和免疫治疗,虽已取得一定疗效,但在耐受性和长期生存率等方面仍存在明显不足。今后需着重关注与结肠癌转移相关的调控网络,以进一步阐述结肠癌的转移机制,为开发、研究更加高效、低毒的治疗方法奠定理论基础。
The metastasis mechanism of colon cancer mainly includes epithelial-mesenchymal transition(EMT)of tumor cells,changes in tumor microenvironment,alteration of intestinal flora and abnormal activation of various molecular pathways,among which EMT plays a key role in metastasis.At present,individualized strategies are mostly used in clinical treatment.Treatment methods include surgery,chemotherapy,targeted therapy and immunotherapy.Although some curative effects have been achieved,there are still obvious deficiencies in tolerance and long-term survival rate.In the future,it is necessary to focus on the regulatory network related to colon cancer metastasis,so as to further explain the metastasis mechanism of colon cancer and lay a theoretical foundation for the development of more efficient and low-toxic treatment methods.
作者
孙立杰
SUN Lijie(Department of Gastroenterology of Affiliated Hospital of Chifeng University,Chifeng 024050 Inner Mongolia,China)
出处
《中国民康医学》
2025年第13期11-14,共4页
Medical Journal of Chinese People’s Health
关键词
结肠癌
转移机制
治疗方法
研究进展
Colon cancer
Metastasis mechanism
Treatment method
Research progress
作者简介
孙立杰(1983.09-),女,汉族,内蒙古赤峰人,硕士研究生,副主任医师,研究方向为消化系统肿瘤的综合治疗。
