摘要
目的:探讨进展期结直肠癌患者术前、术后血清CXCL8表达变化及其临床病理学因素的关系.方法:采用流式细胞小球微阵列术(CBA)检测16例进展期结直肠癌患者术前及术后10d血清CXCL8水平,并与健康自愿者对比.分析患者术前、术后血清CXCL8变化与其临床病理学因素的相关性.结果:术前结直肠癌患者血清CXCL8水平高于术前和术后健康自愿者(13.06μg/Lvs4.40μg/L,7.70μg/L,P<0.05);术后血清CXCL8水平高于健康自愿者,但差别无显著性.不同瘤体大小(≤5.0cm与>5.0cm)间,术前(P<0.05)、术后(<0.05)血清CXCL8比较,前者均低于后者.不同年龄组(<65岁与≥65岁)、病灶部位(右侧与左侧)、T分期(T2与T3-4)、N分期(N0与N1-2)、分化程度(高、中分化与低分化)间,术前、术后血清CXCL8水平差别无显著性.术前血清CXCL8水平与原发灶T分期、N分期、分化程度、术前CEA、术前CA19-9之间无相关性.结论:CXCL8参与结直肠癌的演进;进展期结直肠癌患者术前/术后外周血CXCL8升高,是影响临床治疗与预后评价的重要生物学因素,其临床病理学意义独立于TNM系统.
AIM：To investigate the correlation between serum levels of CXCL8 and clinicopathological features in patients with advanced colorectal cancer.METHODS：Ten healthy volunteers and 16 patients with advanced colorectal cancer were recruited for this study.Serum samples were collected prior to operation and 10 days post-operation to measure the concentrations of CXCL8by cytometric bead array.RESULTS：The mean serum level of CXCL8 was significantly higher in pre-treated patients than in post-treated patients and healthy volunteers（13.06 μg/L vs 4.40 μg/L,7.70 μg/L,both P 0.05）.No significant difference was noted in mean serum level of CXCL8 between post-treated patients and healthy volunteers.Age,tumor site,T and N stage,and tumor differentiation showed no signif icant influence on the levels of serum CXCL8.Preoperative and postoperative serum levels of CXCL8 were signif icantly lower in patients with tumor ≤5.0 cm in diameter than in those with tumor 5.0 cm.Serum CXCL8 levels were not associated with T and N stage,tumor differentiation,preoperative levels of CEA,CA19-9,or platelet count.CONCLUSION：CXCL8 is involved in the evolution of colorectal cancer.Higher levels of serum CXCL8 were detected in patients with advanced colorectal cancer.Serum CXCL8 is an important parameter for evaluation of treatment response and prognosis in patients with advanced colorectal cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第7期700-704,共5页
World Chinese Journal of Digestology
基金
辽宁省博士启动基金资助项目
No. 20071029~~
作者简介
张忠国，副主任医师，主要从事结直肠癌干细胞恶性转化与演进的分子机制方面的研究 通讯作者：张忠国，博士，副主任医师，110042，辽宁省沈阳市大东区小河沿路42号，辽宁省肿瘤医院大肠外科oncologist．china@yahoo．com．cn
