摘要
骨癌痛(cancer-induced bone pain,CIBP)不仅给癌症患者带来巨大痛苦,也降低其生活质量和自信心。导致CIBP的机制是复杂的,并随着癌症的进展而发生演变。目前治疗手段效果有限且存在不良反应。中医药在治疗CIBP方面具有一定优势,但相关镇痛机制有待深入探讨。建立典型、稳定、易重复的动物模型是进一步研究疾病发病机制和验证干预措施有效性的前提和基础。本文总结近3年常用的CIBP动物模型造模方法,并总结CIBP动物模型在中医药相关镇痛机制研究的应用,以期为今后的CIBP研究提供方向。
Cancer-induced bone pain(CIBP)causes substantial suffering for cancer patients and also diminishes their quality of life and self-esteem.The mechanisms underlying CIBP are complex and evolve progressively with cancer advancement.Current treatment options show limited efficacy and are often accompanied by adverse effects.Traditional Chinese medicine demonstrates potential advantages in managing CIBP;however,the mechanisms of action remain poorly understood and require further investigation.The development of a standardized,stable,and reproducible animal model is crucial to advancing research on disease pathogenesis and verifying the effectiveness of therapeutic interventions.This review considers recent method for modeling CIBP in animals and summarizes the application of these models in studies of traditional Chinese medicine mechanisms,with the aim of guiding future research directions in CIBP.
作者
张俊
田丽娅
黄琴
李枋霏
曹杰
王维
ZHANG Jun;TIAN Liya;HUANG Qin;LI Fangfei;CAO Jie;WANG Wei(Chongqing University Cancer Hospital,Chongqing 400030,China;College of Acupuncture and Massage,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《中国实验动物学报》
北大核心
2025年第6期925-934,共10页
Acta Laboratorium Animalis Scientia Sinica
基金
重庆市科卫联合中医药科研项目资助项目(2024ZYDB002)
重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0501)。
关键词
骨癌痛
动物模型
中医药
镇痛机制
cancer-induced bone pain
animal models
traditional Chinese medicine
mechanisms
作者简介
张俊,男,硕士,主治医师,研究方向:中西医结合防治肿瘤常见病及并发症。Email:963496414@qq.com;通信作者:王维,女,博士,主任医师,博士生导师,研究方向:中医药防治恶性肿瘤。Email:abbystina98@163.com。
