氨氯地平联合艾司唑仑治疗老年高血压伴睡眠障碍患者的疗效研究

A Clinical Study on the Efficacy of Amlodipine Combined with Estazolam in Treating Older Adult Patients with Hypertension and Comorbid Sleep Disorders

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摘要目的:分析老年高血压伴睡眠障碍患者应用氨氯地平联合艾司唑仑治疗的实际疗效。方法:选取2024年2月至2025年2月福建省泉州市第一医院心血管内科收治的高血压伴睡眠障碍老年患者80例作为研究对象,按照随机数字表法分为对照组和观察组,每组40例。对照组给予氨氯地平治疗,观察组在对照组基础上联合给予艾司唑仑治疗。治疗前和治疗8周后,采用电子血压计测量患者的收缩压和舒张压,采用匹兹堡睡眠质量指数(PSQI)量表评估2组患者睡眠质量的差异,采用生命质量综合评定问卷(GQOLI-74)评估2组患者生命质量的改善效果,并比较2组患者的治疗效果。结果:治疗后,2组患者收缩压及舒张压均有所降低,且观察组显著低于对照组,差异有统计学意义(P<0.05);治疗后,2组患者PSQI评分均有所降低,且观察组显著低于对照组,差异有统计学意义(P<0.05);治疗后,2组患者GQOLI-74量表评分均有提高,且观察组显著高于对照组,差异有统计学意义(P<0.05)。结论:针对老年高血压伴睡眠障碍患者,采用氨氯地平与艾司唑仑联合治疗的方案成效显著,该疗法不仅能够显著调控血压水平,还能有效优化睡眠质量,进而提升患者的生命质量。 Objective:To analyze the clinical efficacy of amlodipine combined with estazolam in treating older adult patients with hypertension and comorbid sleep disorders.Methods:A total of 80 older adult patients with hypertension and sleep disorders admitted to the Department of Cardiovascular Medicine at Quanzhou First Hospital(Fujian Province)were enrolled between February 2024 and February 2025.Participants were randomly divided into a control group and an observation group(n=40 per group)using a random number table.The control group received amlodipine monotherapy,and the observation group received estazolam as an add-on therapy to amlodipine.Before and after 8 weeks of treatment,the patients′systolic and diastolic blood pressure were measured by electronic sphygmomanometer,the difference of sleep quality between the two groups was evaluated by Pittsburgh Sleep Quality Index(PSQI),and the improvement effect of quality of life between the two groups was evaluated by GQOLI-74,and the therapeutic effects of the two groups were compared.Results:After treatment,both groups showed reductions in systolic and diastolic blood pressure,with the observation group demonstrating significantly lower values than the control group(P<0.05).Similarly,Pittsburgh Sleep Quality Index(PSQI)scores decreased in both groups post-treatment,but were significantly lower in the observation group compared to controls(P<0.05).Furthermore,Generic Quality of Life Inventory-74(GQOLI-74)scores increased in both groups after therapy,with the observation group exhibiting significantly higher improvements versus the control group(P<0.05).Conclusion:For older adult patients with hypertension and sleep disorder,the amlodipine-estazolam combination therapy demonstrated significant efficacy.This therapy can not only effectively regulated the blood pressure level,but also effectively optimized the quality of sleep,thereby enhancing the quality of life of patients.

作者黄杰翔 HUANG Jiexiang(The First Hospital of Quanzhou,Fujian Province,Quanzhou 362000,China)

机构地区福建省泉州市第一医院

出处《世界睡眠医学杂志》 2025年第4期761-764,共4页 World Journal of Sleep Medicine

关键词老年患者高血压睡眠障碍氨氯地平艾司唑仑生命质量临床疗效睡眠质量 Older adult patients Hypertension Sleep disorders Amlodipine Eszolam Quality of life Clinical efficacy Sleep quality