摘要
目的通过总结孟德尔随机化(Mendelian randomization,MR)研究的证据来评估行为和营养相关因素与颅内动脉瘤(intracranial aneurysm,IA)的关联,为进一步阐明IA的病因和发病机制提供线索。方法系统检索PubMed、Embase、Web of Science、中国知网和万方数据知识服务平台等中英文数据库,筛选出行为和营养相关因素与IA关联的MR研究,采用叙述整合的方法将纳入文献归类,进行定性系统综述。结果共纳入2018-2023年发表的12篇文献,其中4篇被判定为高质量研究。这些研究探讨了吸烟、咖啡摄入、体力活动、饮酒和饮茶等行为因素及同型半胱氨酸、血清镁、血清铁、血清钙、多不饱和脂肪酸等营养因素与IA及其亚型的关系,但存在重复发表的问题。4项基于同一欧洲人群、不同工具变量筛选标准的MR研究均支持吸烟是IA及其亚型的危险因素;关于咖啡摄入、体力活动、同型半胱氨酸、血清镁、血清钙与IA及其亚型的关联结果不同;各有1项MR研究提示血清铁和多不饱和脂肪酸与IA及其亚型存在关联。结论吸烟增加IA及其亚型发病风险,对于其他行为和营养相关因素与IA及其亚型的关联需要进一步地深入研究。MR研究本身存在局限性,需综合其他证据,谨慎进行因果推断。
Objective To evaluate the association between behavioral and nutrient-related factors and intracranial aneurysm(IA)by summarizing evidences from Mendelian randomization(MR)studies for further elucidating the etiology and pathogenesis of IA.Methods PubMed,Embase,Web of Science,CNKI and Wanfang were systematically searched to screen out related studies.The included literatures were classified by narrative integration method for qualitative systematic review.Results A total of 12 studies published between 2018 and 2023 were included,of which 4 were judged to be of high quality.These studies explored the relationship between behavior(smoking,coffee intake,physical activity,alcohol and tea consumption)and nutrition-related factors(homocysteine,serum magnesium,serum iron,serum calcium,and polyunsaturated fatty acids)and IA and its subtypes,but they had the problem of being published repeatedly.Four MR studies based on different instrumental variables screening criteria in the same european population all supported smoking as a risk factor for IA and its subtypes;the results regarding coffee intake,physical activity,homocysteine,serum magnesium,and serum calcium were discrepancy.One MR study each suggested that serum iron and polyunsaturated fatty acids were associated with IA and its subtypes.Conclusions Smoking can increase the risk of IA and its subtypes,the association of other behavioral and nutrient-related factors with IA and its subtypes needs further investigation.The MR study itself has limitations,which requires careful causal inference based on other evidences.
作者
王雨格
刘珺宇
曹芳
严俊霞
WANG Yuge;LIU Junyu;CAO Fang;YAN Junxia(Department of Epidemiology and Health Statistics,Xiangya School of Public Health,Central South University,Changsha 410013,China;Department of Pharmacology,Kyoto University,Graduate School of Medicine,Kyoto University,Kyoto 606-8501,Japan)
出处
《中华疾病控制杂志》
北大核心
2025年第5期606-615,共10页
Chinese Journal of Disease Control & Prevention
基金
中南大学研究生科研创新项目(1053320232002)
中南大学研究生教学案例库建设项目(2025ALK009)。
关键词
孟德尔随机化
颅内动脉瘤
行为和营养相关因素
Mendelian randomization
Intracranial aneurysm
Behavioral and nutrient-related factors
作者简介
通信作者:严俊霞,E-mail:junxia_yan@csu.edu.cn。
