摘要
目的:研究注射用血塞通与血塞通注射液不良反应(ADR)的发生规律,为临床用药安全提供参考。方法:检索中国期刊全文数据库、维普数据库、万方数据库收载的注射用血塞通和血塞通注射液ADR的个案报道,检索时限为1993年1月1日-2024年4月1日,统计并分析ADR发生特点。结果:共检索到注射用血塞通ADR相关文献38篇,提取病例53例,血塞通注射液ADR相关文献24篇,共37例。注射用血塞通与血塞通注射液不良反应发生患者以60岁以上人群居多,占比分别为39.62%和44.12%,用药剂量合理率分别为86.79%与47.16%,溶剂选择与用量的合理率分别为94.34%与76.47%。两种剂型ADR的发生主要集中在用药30 min及用药2 d以上,累及多个系统/器官,两种剂型发生不良反应主要集中于皮肤及其附件系统,具体表现为皮肤水泡、红疹、瘙痒等。结论:通过对比血塞通两种剂型不良反应的发生情况,为临床用药安全提供参考依据,临床应严格按药品说明书的适应证及用法用量使用血塞通,用药后30 min内应加强监护,以便发生ADR时能及时采取措施,以降低用药风险,提高临床疗效。
Objective:To study the occurrence of adversedrugreaction(ADR)for Xuesaitong injection and Xuesaitong injection,and to provide reference for clinical drug safety.Methods:The ADR cases of Xuesaitong for injection and Xuesaitong injection collected in China Journal full-text database,Weipu database and Wanfang database were searched from January 1,1993 to April 1,2024,and the occurrence characteristics of ADR were analyzed statistically.Results:A total of 38 literatures related to Xuesaitong ADR for injection were retrieved,53 cases were extracted,24 literatures related to Xuesaitong injection,37 cases in total.The majority of patients with adverse reactions of Xuesaitong and Xuesaitong injection were over 60 years old,accounting for 39.62%and 44.12%,respectively.The rational rate of dosage was 86.79%and 47.16%,and the rational rate of solvent selection and dosage was 94.34%and 76.47%,respectively.ADR of the two dosage forms mainly occurred within 30min of administration and more than 2 days of administration,involving multiple systems/organs.The adverse reactions of the two dosage forms of Xuesaitong were mainly concentrated in the skin and its accessory system,which were manifested as skin blisters,rash and pruritus.Conclusion:By comparing the occurrence of adverse reactions of the two dosage forms of Xuesaitong,we can provide reference for clinical drug safety.Xuesaitong should be used in strict accordance with the indications and usage and dosage of the drug instructions,and monitoring should be strengthened within 30 minutes after medication,so that timely measures can be taken when ADR occurs,so as to reduce the risk of medication and improve clinical efficacy.
作者
窦晨
罗红梅
黄金娥
张亚浩
陈健平
秀花
Dou Chen;Luo Hongmei;Huang Jin e;Zhang Yahao;Chen Jianping;Xiu Hua(Anning Hospital of Traditional Chinese Medicine,Kunming 650300,China)
出处
《亚太传统医药》
2025年第6期253-256,共4页
Asia-Pacific Traditional Medicine
基金
昆明市卫生科技人才培养项目[2023-SW(后备)-45]
云南中医药大学校院联合基金项目(XYLH202355)。
关键词
血塞通
药品不良反应
中药注射液
合理用药
Xuesaitong
Adverse Drug Reactions
Chinese Medicine Injection
Rational Drug Use
作者简介
窦晨(1996-),女,硕士,安宁市中医医院药师,研究方向为临床药学;通讯作者:罗红梅(1985-),女,硕士,安宁市中医医院主管药师,研究方向为临床药学。E-mail:409264769@qq.com。
