摘要
背景:H型血管(CD31hiEmcnhi)因独特的功能为深入理解血管介导的骨代谢调控机制提供了新的视角和切入点,引发了骨科学研究范式从“骨本位”向“骨-血管整合”的重要转变。目的:基于H型血管领域的文献数据进行可视化分析,探讨该领域的研究热点和前沿趋势。方法:系统检索CNKI和Web of Science核心合集中与H型血管相关的中英文文献,文献检索时限为2014-2024年。采用CiteSpace 6.2.R4信息可视化软件对文献的发表国家、作者、机构、关键词、时间线视图等进行可视化分析。结果与结论:①共纳入中文文献59篇、英文文献185篇。自2014年提出H型血管概念以来,相关研究文献数量逐年增加,中国在该领域的研究处于领先地位,主要研究机构包括南方医科大学、四川大学和上海交通大学等。关键词分析揭示,当前研究热点主要集中在H型血管的生成与调控机制、H型血管在骨生成和骨重塑过程中的作用以及H型血管与骨质代谢相关疾病的关系;此外,出现“诱导膜”“软骨修复”“中医药”等新兴关键词,表明研究正在向多样化和多学科交叉的方向发展。②H型血管在骨骼疾病的发生发展中发挥着关键作用,相关研究对深入理解骨组织的生理与病理过程具有重要意义。未来应进一步探讨H型血管在不同疾病背景下的具体作用机制,推动基础研究成果的临床转化,为骨骼疾病的预防和治疗提供新的思路与策略。
BACKGROUND:H-type vessels(CD31hiEmcnhi)possess unique functionalities that offer new perspectives and entry points for comprehensively understanding the mechanisms of vascular-mediated bone metabolism regulation.This has triggered a significant paradigm shift in bone science research from a“bone-centric”approach to an“integrative bone-vascular”framework.OBJECTIVE: To perform a visual analysis based on literature data in the field of H-type vessels, aiming to identify research hotspots and emerging trends. METHODS: A systematic search was conducted in the CNKI and Web of Science databases for English and Chinese publications related to H-type vessels, covering the period from 2014 to 2024. The CiteSpace 6.2.R4 information visualization software was utilized to analyze and visualize data on publication countries, authors, institutions, keywords, and timeline views. RESULTS AND CONCLUSION: (1) A total of 59 Chinese and 185 English publications were included in the analysis. Since the introduction of the H-type vessel concept in 2014, the number of related research publications has been steadily increasing, accompanied by a significant growth in academic output. China leads the research in this domain, with major institutions including Southern Medical University, Sichuan University, and Shanghai Jiao Tong University. Keyword analysis indicated that current research hotspots primarily focus on the generation and regulatory mechanisms of H-type vessels, their roles in bone formation and remodeling, and their associations with bone metabolic diseases. Additionally, emerging keywords such as “induced membrane,” “cartilage repair,” and “traditional Chinese medicine” suggest that research is progressively moving towards diversification and multidisciplinary integration. (2) H-type vessels play a crucial role in the development and progression of bone diseases, and relevant studies are pivotal for a deeper understanding of the physiological and pathological processes of bone tissue. Future research should further elucidate the specific mechanisms of H-type vessels in various disease contexts and promote the clinical translation of basic research findings. These efforts will provide innovative ideas and strategies for the prevention and treatment of bone-related diseases.
作者
彭皓
陈奇刚
申震
Peng Hao;Chen Qigang;Shen Zhen(Yunnan Normal University,Kunming 650500,Yunnan Province,China;Department of Rehabilitation,The Third Affiliated Hospital of Yunnan University Chinese Medicine,Kunming 650011,Yunnan Province,China)
出处
《中国组织工程研究》
北大核心
2026年第3期760-769,共10页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金项目(82360943),项目负责人:申震
云南省“兴滇英才支持计划”青年人才专项项目(XDYC-QNRC-2022-0609),项目负责人:申震
云南省中医联合专项项目(202101AZ070001-257,202101AZ070001-123),项目负责人:申震
云南省基础研究专项项目(202201AU070120),项目负责人:申震。
作者简介
第一作者:彭皓,男,1998年生,广东省湛江市人,汉族,硕士,主要从事肌骨康复、运动康复研究,https://orcid.org/0009-0001-1795-6717;通讯作者:申震,博士,主治医师,云南中医药大学第三附属医院康复科,云南省昆明市650011;通讯作者:陈奇刚,主任医师,教授,硕士生导师,云南中医药大学第三附属医院康复科,云南省昆明市650011。
