摘要
炎症性肠病(inflammatory bowel disease,IBD)是一种非特异性复发性的肠道炎症性疾病。其发病机制尚不明确,越来越多的研究表明线粒体功能障碍在IBD的发生机制中起到重要作用。基于线粒体功能障碍对肠道屏障的影响,本综述对IBD的发生机制进行全面回顾和梳理,重点探讨能量供应不足、线粒体活性氧(mitochondrial reactive oxygen species,mtROS)过载以及线粒体质量控制系统失调对肠上皮屏障的影响,以期为IBD的基础研究和临床防治提供新依据。
Inflammatory bowel disease(IBD)is a non-specific recurrent inflammatory disease of the intestine.More and more studies have shown that mitochondrial dysfunction plays an important role in the pathogenesis of IBD.Based on the effect of mitochondrial dysfunction on intestinal barrier,this review comprehensively review and summarize the mechanism of IBD,focusing on the effects of insufficient energy supply,mitochondrial reactive oxygen species(mtROS)overload and mitochondrial quality control system disorder on intestinal epithelial barrier,in order to provide a new basis for the basic research and clinical prevention and treatment of IBD.
作者
张博
李勇
董娟
张悦
李心语
王佩
刘家铭
Zhang Bo;Li Yong;Dong Juan;Zhang Yue;Li Xinyu;Wang Pei;Liu Jiaming(Department of Proctology and Enterology,Qingyang Hospital of Traditional Chinese Medicine·The Fifth Affiliated Hospital of Gansu University of Chinese Medicine,Qingyang 745000,China;Clinical College of Traditional Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;College of Acupuncture and Massage,Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《中国组织化学与细胞化学杂志》
2025年第2期184-189,194,共7页
Chinese Journal of Histochemistry and Cytochemistry
基金
甘肃省哲学社会科学规划项目(SH036)。
关键词
炎症性肠病
线粒体功能障碍
肠上皮屏障
Inflammatory bowel disease
mitochondrial dysfunction
intestinal epithelial barrier
作者简介
张博,男(1988年),汉族,副主任医师;通讯作者:李勇,3144196718@qq.com。
