摘要
目的探讨使用窄谱强脉冲光(DPL)联合氨甲环酸治疗面部黄褐斑的效果和患者满意度。方法纳入2022年11月至2024年8月在高邮市人民医院接受治疗的90例黄褐斑患者,随机分为3组,每组30例。药物组口服氨甲环酸片0.25 g/次,2次/d,共6个月;DPL组采用DPL治疗,每月1次,共4次;联合组采用DPL联合氨甲环酸治疗,方法同前两组。比较患者治疗前后黄褐斑皮损面积及严重指数评分(MASI)。治疗结束后评价疗效,调查患者满意度,并观察不良反应及复发情况。结果治疗后,联合组的MASI下降百分比[(62.20±19.14)%]高于DPL组[(48.10±22.18)%]和药物组[(45.32±20.74)%],有效率(80.00%)明显高于DPL组(53.33%)和药物组(50.00%),患者满意度(80.00%)亦明显高于DPL组(53.33%)和药物组(50.00%),差异均有统计学意义(均P<0.05)。三组患者均无明显不良反应。6个月后随访,联合组复发0例,DPL组复发2例,药物组复发1例。结论DPL联合氨甲环酸治疗黄褐斑安全、有效。
Objective To investigate the efficacy and patients'satisfaction of combing narrowband intense pulsed light(DPL)with tranexamic acid for the treatment of facial melasma.Methods Ninety melasma patients treated at Gaoyou People's Hospital between November 2022 and August 2024 were randomly divided into three groups(30 patients per group).The medication group received oral tranexamic acid tablets(0.25 g twice daily for 6 months),while the DPL group underwent DPL treatment once per month for 4 sessions.The combination group received both interventions following the same protocols as the other two groups.The melasma area and severity index(MASI)scores were compared before and after the treatment.The efficacy and patients'satisfaction were evaluated after the treatment.Adverse reactions and recurrence rates were also monitored.Results After the treatment,the combination group achieved a greater reduction in MASI scores than the other two groups(62.20±19.14%vs.48.10±22.18%in the DPL group and 45.32±20.74%in the medication group,P<0.05).Moreover,both total effective rate and patients'satisfaction scores were higher in the combination group than the other groups(80.00%vs.53.33%in the DPL group and 50.00%in medication group,P<0.05).No significant adverse reactions were observed across groups.At six-month follow-up,no recurrence was observed in the combination group,while 2 cases were reported in the DPL group and 1 case in the medication group.Conclusion The combination of DPL and tranexamic acid represents a safe and effective approach for the management of melasma.
作者
薛呈毅
郭开忠
张国成
陈军
XUE Chengyi;GUO Kaizhong;ZHANG Guocheng;CHEN Jun(Department of Dermatology,Gaoyou People's Hospital,Gaoyou 225600,China;Institute of Dermatology,Chinese Academy of Medical Sciences,Nanjing 210000,China;Department of Dermatology,Fourth Affiliated Hospital of Nanjing Medical University,Nanjing 210000,China)
出处
《皮肤性病诊疗学杂志》
2025年第3期190-195,共6页
Journal of Diagnosis and Therapy on Dermato-venereology
关键词
黄褐斑
氨甲环酸
窄谱强脉冲光
melasma
tranexamic acid
narrowband intense pulsed light
作者简介
通信作者:陈军,副主任医师,E-mail:spingchenjun@163.com。
