摘要
本研究采用化学发光免疫分析法检测2022年10月至2023年5月重庆口岸健康体检人群血清25-羟维生素D[25(OH)D]水平。结果显示该人群血清25(OH)D水平为13.24(10.56,16.63)ng/ml,存在不同程度维生素D缺乏。其中维生素D充足、不足、缺乏、严重缺乏分别占2.09%、11.78%、66.38%、19.75%。性别差异分析表明女性严重缺乏(29.07%)高于男性(13.32%)。男性血清25(OH)D水平高于女性,不同性别血清25(OH)D水平、维生素D营养状况存在统计学差异(Z=7.38,P<0.001;Z=6.19,P<0.001)。年龄相关研究显示,血清25(OH)D水平随着年龄的增长逐渐增高,≥60岁年龄组25(OH)D水平高于其他年龄组,不同年龄组血清25(OH)D水平、维生素D营养状况存在着统计差异(H=149.61,P<0.001;H=105.67,P<0.001)。同年龄组女性25(OH)D水平低于男性,≤44岁年龄组、45—59岁年龄组男、女血清25(OH)D水平存在统计学差异(Z=5.45,P<0.001;Z=2.22,P=0.03),≥60岁年龄组男、女血清25(OH)D水平无统计学差异(Z=1.81,P=0.06)。≤44岁年龄组不同性别维生素D营养状况比较存在统计学差异(P<0.001),45—59岁年龄组、≥60岁年龄组不同性别维生素D营养状况比较无统计学差异(P>0.05)。基于上述研究,发现重庆口岸健康体检人群维生素D存在不同程度缺乏。针对维生素D缺乏人群实施筛查-干预-评估高效管理模式,对改善维生素D营养水平,更好地预防维生素D缺乏导致的慢性疾病具有重要意义。
The serum 25-hydroxyvitamin D[25(OH)D]levels in healthy people examined at Chongqing Port from October 2022 to May 2023 were detected by chemiluminescence immunoassay.The resultant data unveiled that the serum 25(OH)D level 13.24(10.56,16.63)ng/ml,and there were different levels of vitamin D deficiency.Adequate,insufficient,deficient and severely deficient vitamin D accounted for 2.09%,11.78%,66.38%and 19.75%.Analysis of gender differences showed that women(29.07%)were more severely deficient than men(13.32%).Serum 25(OH)D level in males was higher than that in females,and there were statistical differences in serum 25(OH)D level and vitamin D nutritional status between different genders(Z=7.38,P<0.001;Z=6.19,P<0.001).Age-dependent reserch shows that the serum 25(OH)D level increased gradually with the increase of age,and the serum 25(OH)D level in≥60 years old age group was higher than that in other age groups.There were statistical differences in serum 25(OH)D level and vitamin D nutritional status among different age groups(H=149.61,P<0.001;H=105.67,P<0.001).The level of 25(OH)D in females was lower than that in males in the same age group,and there were statistically significant differences in serum 25(OH)D levels between males and females in≤44 and 45-59 age groups(Z=5.45,P<0.001;Z=2.22,P=0.03),There was no significant difference in serum 25(OH)D between male and female aged≥60 years(Z=1.81,P=0.06).There were statistical differences in vitamin D nutritional status between different sexes in≤44 years old age group(P<0.001),and no statistical differences in vitamin D nutritional status between 45-59 years old age group and≥60 years old age group(P>0.05).Based on the aforementioned research,vitamin D deficiency exists in healthy people at Chongqing port.The implementation of an effective screening,intervention and evaluation model for the population with vitamin D deficiency is of crucial significance in terms of enhancing vitamin D nutritional levels and more effectively preventing chronic diseases resulting from vitamin D deficiency.
作者
张朓
刘启军
钟进
文海燕
ZHANG Tiao;LIU Qijun;ZHONG jin;WEN Haiyan(Chongqing International Travel Healthcare Center(Chongqing Customs Port Outpatient),Chongqing 401147,China)
关键词
维生素D
营养状况
缺乏
改善措施
口岸
vitamin D
nutritional status
deficient
improvement measure
作者简介
第一作者:张朓(1976-),女(汉族),重庆人,医学学士,副主任医师,研究方向:口岸卫生检疫、传染病、特别是新发传染病、群体性不明原因疾病、健康体检、预防接种、旅行医学咨询。E-mail:609916007@qq.com;通信作者:文海燕,E-mail:wenhaiyan2001@qq.com。
