摘要
目的调查甘肃省健康成人的维生素D状况，并评价其与相关因素的关系。方法采用分层整群随机抽样的方法，于2014年6月至2015年11月，在甘肃省7个地区抽取18～79岁5年以上的常住居民11 157名（男性4 740名、女性6 417名），并进行问卷调查、体格检查、生化检查和骨密度检测。结果甘肃省成人血清25羟维生素D[25（OH）D]平均水平为（16.07±9.40）μg/L；维生素D严重缺乏（〈10 μg/L）、缺乏（≥10μg/L且〈20 μg/L）、不足（≥20 μg/L且〈30 μg/L）、正常（≥30 μg/L）分别为17.3%、64.6%、11.8%和6.3%。维生素D缺乏的独立危险因素包括较年轻者、女性，而日照、运动和钙剂的补充为保护性因素（P〈0.05）。血清25（OH）D的水平与血清甲状旁腺激素呈负相关（r＝－0.279，P〈0.001），与血钙（r＝0.239，P〈0.001）、血磷（r＝0.090，P＝0.018）、血清低密度脂蛋白（r＝0.100，P＝0.008）和体质量指数（r＝0.093，P＝0.014）呈正相关。在所有受试者中，血清25（OH）D的水平与骨密度无相关性（P〉0.05）。结论维生素D缺乏普遍存在于甘肃地区成年人群，尤其多见于女性和较年轻者，并受日照、活动、钙剂等因素影响。
ObjectiveTo investigate the prevalence of vitamin D deficiency and its associated metabolic risk factors in the healthy adults in Gansu Province, a western province of China.MethodsThrough stratified, multistage probability population sampling, 11 300 adults （4 740 men and 6 417 women aged 18-79 years） who had been living in their current residence for at least 5 years were arbitrarily chosen from seven representative geographical cities in Gansu Province from June 2014 to December 2015. The data obtained from a questionnaire-based survey, anthropometric and biochemical assessments, and areal bone mineral density measurement were collected and analyzed.ResultsThe overall mean serum 25（OH）D was （16.07±9.40） μg/L. The prevalence of severe deficiency （〈10 μg/L）, deficiency （≥10 μg/L and 〈20 μg/L）, insufficiency （≥20 μg/Land 〈30 μg/L）, and sufficiency （≥30 μg/L） among these adults were 17.3%, 64.6%, 11.8%, and 6.3%, respectively. The significant predictors of vitamin D deficiency included younger age and female sex（P〈0.05）, whereas sun exposure, physical activity, and calcium supplementation were protective （P〈0.05）. Serum 25（OH）D was inversely associated with parathyroid hormone （r=-0.279, P〈0.001） and positively associated with serum calcium （r= 0.239, P〈0.001）, serum phosphorus （r=0.090, P=0.018）, low-density lipoprotein cholesterol（r=0.100, P=0.008）, and body mass index （r=0.093, P=0.014）. The 25（OH）D concentration showed no significant correlation with bone mineral density （P〉0.05）.ConclusionsVitamin D deficiency is highly prevalent among adult populations in Gansu, northwestern of China, and is largely attributed to younger age and female sex. The cumulative effects of factors including sun exposure, physical activity, and calcium supplementation play an influential role in maintaining vitamin D levels.
出处
《中华临床营养杂志》
CAS
CSCD
2017年第4期240-245,共6页
Chinese Journal of Clinical Nutrition
作者简介
通信作者：田利民，E—mail：tlm6666@sina．com
