摘要
玄府是气升降出入的道路门户,人体基于玄府功能、脾胃升降、三焦升降的出入运化,具有实时性、整体性和动态平衡性等特点,在脏腑精神、形体官窍等的生成和疾病的发生发展中发挥重要作用。氧化应激在变应性鼻炎(allergic rhinitis,AR)炎症反应和鼻黏膜上皮细胞病理损伤与免疫活性调控中作用广泛,是加重AR症状和体征的重要影响机制,与玄府-气液-三焦功能失常而致病的病机高度一致。近年来,AR的氧化应激和抗氧化剂研究受到越来越多的关注,活性氧、呼出气一氧化氮、丙二醛等的增多成为AR早期诊断的有利依据。大量通过抗氧化发挥抗炎、抗过敏和免疫调控作用的经典方、经验方和新型中药外用制剂的研究,进一步表明中医药治疗AR的积极作用,为从现代医学角度认识AR中医病机奠定基础。因此,该文通过系统讨论玄府-气液-三焦与鼻鼽关系,结合氧化应激机制认识玄府-气液-三焦病机,从而从外用中药制剂以开鼻玄府,配发散、搜剔、香窜、温通、通下,开玄防病与中土升降枢转,以及温阳化气行水并清风抑木,探究基于氧化应激从玄府-气液-三焦论治儿童AR的验法。
Sweat pores function is the ascending and descending of Qi.The human body maintains a continuous,holistic,and dynamic balance through the functioning of sweat pores as well as the Qi movement and transformation in the spleen,stomach,and triple energizer.Sweat pores play a crucial role in the generation and development of Zang-fu organs,essence and spirit,and body and orifices,as well as in the onset and progression of diseases.Oxidative stress significantly affects the regulation of inflammation in allergic rhinitis(AR),induces the pathological damage to nasal epithelial cells,and alters immune activity,serving as a key mechanism exacerbating AR symptoms.This mechanism closely aligns with the pathogenesis associated with dysfunction in the sweat pore-Qi-triple energizer system.In recent years,oxidative stress and antioxidants in AR have received increasing attention.Elevated levels of reactive oxygen species,fractional exhaled nitric oxide,and malondialdehyde have become key indicators for the early diagnosis of AR.Classical prescriptions,empirical prescriptions,and newly developed preparations of traditional Chinese medicine(TCM)for external use with anti-inflammatory,anti-allergic,and immune-regulatory effects via antioxidant pathways have demonstrated definite efficacy in treating AR.This provides a basis for understanding the pathogenesis of AR in TCM from a modern medical perspective.Therefore,this paper systematically examines the relationship between the sweat pore-Qi-triple energizer system and AR,incorporating the oxidative stress mechanism into the research on pathogenesis of the disorders.Furthermore,methods for treating AR in children are proposed with TCM preparations for external use which aimed at opening nasal sweat pores,dispersing,searching,channeling with aroma,warming,and dredging,regulating Qi movement in spleen,warming Yang Qi to promote urination,and clearing latent wind to inhibit liver depression.
作者
窦玉珠
戴启刚
DOU Yu-zhu;DAI Qi-gang(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)
出处
《中国中药杂志》
北大核心
2025年第5期1419-1426,共8页
China Journal of Chinese Materia Medica
基金
国家中医药管理局高水平中医药重点学科中医儿科学(南京中医药大学)2023年度开放课题(NZYEK006)
江苏省中医药局科技项目(YB2017001)。
关键词
氧化应激
玄府-气液-三焦
变应性鼻炎
oxidative stress
sweat pore-Qi-triple energizer system
allergic rhinitis
作者简介
通信作者:戴启刚,副教授,副主任医师,主要从事小儿肺脾系疾病机制及临床研究,E-mail:qgdai2006@163.com;窦玉珠,硕士研究生,E-mail:yyyfccqydd@126.com。
