摘要
目的探讨老年女性2型糖尿病患者(type 2 diabetes mellitus,T2DM)与甲状腺结节(thyroid nodule,TN)患病风险的关系。方法回顾性选取2019年9月-2023年8月甘肃省人民医院内分泌科收治的符合住院标准的201例老年女性T2DM患者的临床资料,按是否合并TN分为DTN组(n=122,T2DM合并TN患者)和单纯T2DM组(n=79,无TN的T2DM患者),通过二元Logistic回归分析评估老年女性T2DM患者罹患TN的影响因素。结果DTN组25羟维生素D水平低于单纯T2DM组,空腹血糖水平高于单纯2DM组,差异均有统计学意义(P均<0.05);两组年龄、身高、体重、体重指数、收缩压、舒张压、糖尿病病程、糖化血红蛋白、空腹胰岛素、同型半胱氨酸、甘油三酯、高密度脂蛋白、低密度脂蛋白、血钙、血磷水平比较,差异均无统计学意义(P均>0.05)。二元Logistic回归分析结果显示25羟维生素D、空腹血糖是老年女性T2DM患者罹患TN的影响因素(P均<0.05)。结论血清25羟维生素D、空腹血糖水平是老年女性T2DM患者罹患TN的影响因素,监测其水平对于制订有效的预防和干预措施至关重要。
Objective To investigate the relationship between type 2 diabetes mellitus(T2DM)and the risk of thyroid nodule(TN)in elderly women.Methods The clinical data of 201 elderly female T2DM patients who met the hospital-ization criteria admitted to the Department of Endocrinology,Gansu Provincial People's Hospital from September 2019 to August 2023 were retrospectively selected.They were divided into DTN group(n=122,T2DM patients with TN)and simple T2DM group(n=79,T2DM patients without TN)according to whether they had TN.The risk factors of TN in elderly female T2DM patients were evaluated by binary Logistic regression analysis.Results The level of 25-hydroxyvitamin D in DTN group was lower than that in T2DM group,and the level of fasting plasma glucose were higher than those in T2DM group,and the differences were statistically significant(both P<0.05).There were no sig-nificant differences in age,height,weight,body mass index,systolic blood pressure,diastolic blood pressure,duration of diabetes,glycated hemoglobin A1c,fasting insulin,homocysteine,triglyceride,high-density lipoprotein,low-density lipoprotein,blood calcium and blood phosphorus between the two groups(all P>0.05).Binary Logistic regres-sion analysis showed that 25-hydroxyvitamin D and fasting plasma glucose were the influencing factors for TN in el-derly female patients with T2DM(both P<0.05).Conclusion Serum 25-hydroxyvitamin D and fasting plasma glucose levels are the influencing factors of TN in elderly female patients with T2DM,and monitoring their levels is crucial for the development of effective prevention and intervention measures.
作者
张媛君
刘菊香
钱美伶
常翔
权金星
ZHANG Yuanjun;LIU Juxiang;QIAN Meiling;CHANG Xiang;QUAN Jinxing(Lanzhou University First Clinical Medical College,Lanzhou 730000,Gansu,China;Department of Endocrinology,Gansu Provincial People's Hospital,Lanzhou 730000,Gansu,China;Optometry Center,Gansu Provincial People's Hospital,Lanzhou 730000,Gansu,China;Department of Endocrinology,Wuwei People's Hospital,Wuwei 733000,Gansu,China)
出处
《糖尿病新世界》
2025年第3期9-11,15,共4页
Diabetes New World
基金
甘肃省自然科学基金(22JR5RA657)
武威市自然科学基金(WW23A03RPZ011)
甘肃省人民医院院内青年基金(21GSSYC-11)。
关键词
2型糖尿病
甲状腺结节
老年女性
Type 2 diabetes meillitus
Thyroid nodules
Elderly women
作者简介
张媛君(1985-),女,博士在读,主治医师,研究方向为内分泌与代谢疾病;通信作者:权金星(1972-),男,博士,主任医师,研究方向为内分泌与代谢疾病,E-mail:quanjxxt@163.com。
