摘要
缺血性脑卒中是一种脑血管常见病,主要是指脑血管堵塞引起的缺血缺氧性脑部损害。黄芩苷是从中药黄芩中提取出的一种单体物质,目前已经有实验研究表明其可以减轻脑缺血后的神经损害,且进行了相关的机制研究。文章将从抗凋亡、抗氧化、抗炎、调节自噬、防止血脑屏障损伤5个方面,综述目前黄芩苷对脑缺血后神经保护作用的研究进展,以期为其临床应用提供理论依据。
Ischemic stroke is a common cerebrovascular disease,mainly referring to ischemic hypoxic brain damage caused by cerebral vascular blockage.Baicalin is a monomer extracted from Scutellaria baicalensis Georgi.At present,experimental studies have shown that it can reduce the neurological damage after cerebral ischemia,and related mechanism studies have been carried out.This article will review the research progress of Baicalin on neuroprotective effect after cerebral ischemia from five aspects:anti apoptosis,antioxidant,anti-inflammatory,adjusting autophagy activation and resisting blood-brain barrier damage,in order to provide theoretical basis for its clinical application.
作者
陈雯婷
张玉琴
CHEN Wenting;ZHANG Yuqin(Pharmacy College of Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China)
出处
《中国民族民间医药》
2025年第5期73-78,共6页
Chinese Journal of Ethnomedicine and Ethnopharmacy
关键词
黄芩苷
脑缺血
抗炎
血脑屏障
Baicalin
Cerebral Ischemia
Anti-inflammatory
Blood-brain Barrier
作者简介
陈雯婷(1998-),女,汉族,硕士研究生在读,研究方向为中药药理与临床应用。E-mail:493303863@qq.com;通信作者:张玉琴(1988-),女,汉族,副教授、研究生导师,研究方向为中药药理与临床应用。E-mail:2016003@fjtcm.edu.cn。
