摘要
目的:观察体外反搏联合银杏叶提取物注射液治疗急性脑梗死(ACI)患者的效果。方法:回顾性分析2020年3月至2023年12月该院收治的100例ACI患者的临床资料,按照治疗方案不同将其分为对照组与观察组各50例。对照组给予银杏叶提取物注射液治疗,观察组在对照组基础上联合体外反搏治疗。比较两组临床疗效,治疗前后神经功能缺损程度[美国国立卫生院卒中量表(NIHSS)]评分、残障程度[改良Rankin量表(MRS)]评分、日常生活能力[Barthel指数(BI)]评分、血流动力学指标[大脑中动脉搏动指数(PI)、舒张末期血流速度(Vd)、平均血流速度(Vm)、收缩期峰值血流速度(Vs)]水平、血管内皮功能指标[血管内皮生长因子(VEGF)、一氧化氮(NO)、内皮素-1(ET-1)]水平,以及治疗期间不良反应发生率。结果:观察组治疗总有效率为96.00%(48/50),高于对照组的82.00%(41/50),差异有统计学意义(P<0.05);治疗后,两组BI评分均高于治疗前,且观察组高于对照组,两组NIHSS、MRS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组Vs、Vd、Vm水平均高于治疗前,且观察组高于对照组,两组PI水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组NO、VEGF水平均高于治疗前,且观察组高于对照组,两组ET-1水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:体外反搏联合银杏叶提取物注射液治疗ACI患者可提高治疗总有效率和BI评分,改善血流动力学指标和血管内皮功能指标水平,以及降低NIHSS、MRS评分,效果优于单纯银杏叶提取物注射液治疗。
Objective:To observe effects of external counterpulsation combined with Ginkgo biloba extract in treatment of patients with acute cerebral infarction(ACI).Methods:The clinical data of 100 patients with ACI admitted to this hospital from March 2020 to December 2023 were retrospectively analyzed.According to different treatment plans,they were divided into control group and observation group,50 cases in each group.The control group was treated with Ginkgo biloba extract injection,while the observation group was treated with external counterpulsation on the basis of that of the control group.The clinical efficacy,the neurological deficit degree[National Institutes of Health stroke scale(NIHSS)]score,the disability degree[modified Rankin scale(MRS)]score,the activities of daily living[Barthel Index(BI)]score,the hemodynamic indexes[middle cerebral artery pulsation index(PI),end diastolic blood flow velocity(Vd),mean blood flow velocity(Vm),peak systolic blood flow velocity(Vs)]and vascular endothelial function indexes[vascular endothelial growth factor(VEGF),nitric oxide(NO),endothelin-1(ET-1)]levels before and after the treatment,and the incidence of adverse reactions during the treatment were compared between the two groups.Results:The total effective rate of the observation group was 96.00%(48/50),which was higher than 82.00%(41/50)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the BI scores of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the NIHSS and MRS scores of the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of Vs,Vd and Vm in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the PI levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of NO and VEGF in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the levels of ET-1 in the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:External counterpulsation combined with Ginkgo biloba extract injection in the treatment of ACI patients can improve the total effective rate and the BI scores,improve the levels of hemodynamic indexes and vascular endothelial function indexes,and reduce the NIHSS and MRS scores.Moreover,it is superior to simple Ginkgo biloba extract injection treatment.
作者
任晓如
REN Xiaoru(Department of Neurology of Nanle Zhongxing Hospital,Puyang 457400 Henan,China)
出处
《中国民康医学》
2025年第6期78-81,共4页
Medical Journal of Chinese People’s Health
关键词
体外反搏
银杏叶提取物
急性脑梗死
血流动力学
血管内皮功能
External counterpulsation
Ginkgo biloba extract
Acute cerebral infarction
Hemodynamics
Vascular endothelial function
作者简介
任晓如(1987.11-),女,汉族,河南南乐人,本科,主治医师,研究方向为急性脑梗死、脑梗死后认知障碍治疗。
