摘要
特发性脊柱侧弯是一种严重影响青少年身心健康的脊柱畸形,其病因和发病机制至今不明,部分原因是缺乏合适的建模系统,其中鼠类因其易感性且与人类基因高度相似,而被大量用于建立脊柱侧弯模型。本文讨论了多种建模方法,包括杂交形成脊柱侧弯大鼠、双足大鼠模型、增强瘦素活性诱导模型、雌激素诱导模型、降低体内褪黑素含量以诱导模型、基因修改和无创实验模型诱导脊柱侧凸。这些模型揭示了遗传因素、激素水平和生物力学因素在脊柱侧弯发展中的作用。尽管动物模型无法完全复制人体脊柱,存在局限性,但它们有助于研究脊柱侧弯的发病机制、进展并为未来治疗提供了重要工具,对早期诊断和干预策略的发展具有重要意义。在此,我们总结了鼠类脊柱侧弯模型的发展现状,讨论了其优缺点,并展望了其应用前景。
Idiopathic scoliosis is a spinal deformity that severely affects the physical and mental health of adolescents.The etiology and pathogenesis of idiopathic scoliosis continues to be unknown,partly due to the short-age of appropriate modeling systems,of which rodents have been widely used to model scoliosis due to their suscep-tibility and high genetic similarity to humans.Various of modeling methods are discussed,including inbreeding to produce scoliosis rats,bipedal rat models,enhanced leptin activity induction models,estrogen induction models,lowering melatonin levels in vivo to induce models,genetic modification and non-invasive experimental models to induce scoliosis.These models reveal the role of genetic factors,hormone levels and bio-mechanical factors in the development of scoliosis.Despite the limitations of animal models,which do not exactly mimic the human spine,they help to study the pathogenesis and progression of scoliosis and provide an important tool for the future treat-ment of scoliosis and are important for the development of early diagnosis and intervention strategies.We summa-rize the current state of development of rat scoliosis models,discuss their advantages and disadvantages,and look forward to their application prospects.
作者
张晶
冷寒
李凯
侯栋
杨少博
温剑涛
代长泉
张辰
崔小娟
汪娟
袁晓芸
ZHANG Jing;LENG Han;LI Kai;HOU Dong;YANG Shao-bo;WEN Jian-tao;DAI Chang-quan;ZHANG Chen;CUI Xiao-juan;WANG Juan;YUAN Xiao-yun(Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu,730030,China;Gansu Hospital of Traditional Chinese Medicine,Lanzhou,Gansu,730030,China)
出处
《现代生物医学进展》
2025年第1期184-192,共9页
Progress in Modern Biomedicine
基金
甘肃省联合科研基金重大项目(23JRRA1529)。
作者简介
张晶,硕士研究生,E-mail:1137160044@qq.com;通讯作者:温剑涛,研究生导师,E-mail:dr.wenjiantao@foxmail.com。
