摘要
目的分析2017—2022年汉中市手足口病实验室检测结果,为制定更有效手足口病防控方案提供科学依据。方法收集2017—2022年汉中市各区县临床诊断手足口病病例标本,采用实时荧光PCR法对标本进行核酸检测,采用描述流行病学方法进行统计分析,率的比较采用χ2检验,检验水准α=0.05。结果2017—2022年汉中市共收集手足口病标本1872份,其中阳性1183份,总阳性率为63.19%。阳性标本中其他肠道病毒占比最高为61.45%(727/1183),其次为Cox A16型33.47%(396/1183),EV 71型占比最低为5.07%(60/1183)。手足口病流行存在2个高峰(5至7月和9至11月)。手足口病阳性病例主要集中于汉中市汉台区、南郑区、西乡县、城固县、勉县和洋县。手足口病阳性病例主要以1~4岁儿童为主。结论2017—2022年汉中市手足口病疫情总体平稳,应重视非EV 71型和Cox A16型的肠道病毒检测工作,实时监测手足口病病原谱变化。
Objectives To analyze the laboratory test results of hand-foot-mouth disease(HFMD)in Hanzhong City from 2017 to 2022,and to provide scientific basis for formulating more effective prevention and control plans for HFMD.Methods The Samples of clinically diagnosed cases of HFMD from various districts and counties in Hanzhong City from 2017 to 2022 were collected for nucleic acid detection by real-time fluorescence PCR,statistical analysis was performed by descriptive epidemiology method,and the rate was compared by Chi-square test with the test level α=0.05.Results A total of 1872 samples of HFMD were collected in Hanzhong city from 2017 to 2022,of which 1183 were positive,with a total positive rate of 63.19%.Among the positive samples,the highest proportion of other enterovirus was 61.45%(727/1183),followed by CoxA1633.47%(396/1183),and the lowest proportion of EV 71 was 5.07%(60/1183).There were two peaks in the HFMD epidemic(May-July and September-November).The positive cases of HFMD mainly concentrated in Hantai District,Nanzheng District,Xixiang County,Chenggu County,Mian County and Yang County.The positive cases of HFMD were mainly in children aged 1 to 4 years.Conclusions The HFMD epidemic situation in Hanzhong City from 2017 to 2022 was generally stable,and attention should be paid to the detection of enteroviruses of non-EV 71 and Cox A16 types to monitor the changes of HFMD pathogen spectrum in real time.
作者
张久丁
韩亦非
邓彤
陈真
王苗苗
魏建军
ZHANG Jiuding;HAN Yifei;DENG Tong;CHEN Zhen;WANG Miaomiao;WEI Jianjun(Hanzhong Center for Disease Control and Prevention,Hanzhong 723000,Shaanxi Province,China.)
出处
《预防医学情报杂志》
2025年第2期181-184,192,共5页
Journal of Preventive Medicine Information
关键词
手足口病
肠道病毒
病原学
流行特征
hand-foot-mouth disease
enterovirus
etiology
epidemic characteristics
作者简介
张久丁(1984-),男,硕士,副主任技师,微生物检验技术,E-mail:ring4192@163.com。
