摘要
目的探讨加味阳和汤联合布地奈德福莫特罗粉吸入剂对轻中度慢性持续期支气管哮喘患者的临床疗效。方法118例患者随机分为对照组和观察组,每组59例,对照组给予布地奈德福莫特罗粉吸入剂,观察组在对照组基础上加用加味阳和汤,疗程4周。检测临床疗效、ACT评分、支气管哮喘控制率、肺功能指标(FEV1、PEF、FEV1%、PEF%)、炎症指标(EOS、EOS%、FeNO)、中医证候评分、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组支气管哮喘控制率、ACT评分、PEF升高(P<0.05),中医证候评分降低(P<0.05),以观察组更明显(P<0.05);观察组FEV1、FEV1%、PEF%升高(P<0.05),其中FEV1、PEF%高于对照组(P<0.05);观察组炎症指标降低(P<0.05),其中FeNO低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论加味阳和汤联合布地奈德福莫特罗粉吸入剂可安全有效地缓解轻中度慢性持续期支气管哮喘患者临床症状,改善肺功能和气道炎症反应,提高支气管哮喘控制率。
AIM To explore the clinical effects of Jiawei Yanghe Decoction combined with Budesonide and Formoterol Fumarate Powder for Inhalation on patients with mild to moderate bronchial asthma in chronic and persistent period.METHODS One hundred and eighteen patients were randomly assigned into control group(59 cases)for 4-week administration of Budesonide and Formoterol Fumarate Powder for Inhalation,and observation group(59 cases)for 4-week administration of both Jiawei Yanghe Decoction and Budesonide and Formoterol Fumarate Powder for Inhalation.The changes in clinical effects,ACT score,bronchial asthma control rate,pulmonary function indices(FEV1,PEF,FEV1%,PEF%),inflammatory indices(EOS,EOS%,FeNO),TCM syndrome score and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed increased bronchial asthma control rate,ACT score,PEF(P<0.05),and decreased TCM syndrome score(P<0.05),especially for the observation group(P<0.05);the observation group exhibited increased FEV1,FEV1%,PEF%(P<0.05),among which FEV1,PEF%were higher than those in the control group(P<0.05);the observation group showed decreased inflammatory indices(P<0.05),among which FeNO was lower than that in the control group(P<0.05).No significant difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with mild to moderate bronchial asthma in chronic and persistent period,Jiawei Yanghe Decoction combined with Budesonide and Formoterol Fumarate Powder for Inhalation can safely and effectively alleviate clinical symptoms,improve pulmonary functions,airway inflammatory reactions,and enhance bronchial asthma control rate.
作者
王钰
张惠勇
陈林锦
张正易
李翠
崔洁
苏奔
柏萍
马子风
鹿振辉
WANG Yu;ZHANG Hui-yong;CHEN Lin-jin;ZHANG Zheng-yi;LI Cui;CUI Jie;SU Ben;BAI Ping;MA Zi-feng;LU Zhen-hui(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China)
出处
《中成药》
北大核心
2025年第1期81-86,共6页
Chinese Traditional Patent Medicine
基金
国家自然科学基金项目(82205004,82274263,82274429)
上海市自然科学基金项目(21ZR1463500)
上海市卫健委项目(2022QN003,2022XD027)
上海市申康医院发展中心项目(SHDC2020CR3017A)。
关键词
加味阳和汤
布地奈德福莫特罗粉吸入剂
轻中度支气管哮喘
慢性持续期
肺功能
气道炎症反应
Jiawei Yanghe Decoction
Budesonide and Formoterol Fumarate Powder for Inhalation
mild to moderate bronchial asthma
chronic and persistent period
pulmonary functions
airway inflammatory reactions
作者简介
王钰(1994-),女,博士生,住院医师,从事中医药防治慢性气道疾病研究。Tel:13956061807,E-mail:wangyufish18@126.com;通信作者:鹿振辉(1980-),男,主任医师,博士生导师,从事中医药防治呼吸系统疾病研究。Tel:(021)64385700—2320,E-mail:tcmdoctorlu@163.com。
