摘要
目的 探讨艾司氯胺酮对剖宫产患者术后应激反应及产后抑郁的影响。方法 选择新乡市第一人民医院2020年4月~2022年4月120例产妇为研究对象,采用数字表随机法分为两组,对照组术后常规镇痛,观察组在对照组基础上加用艾司氯胺酮。比较术前、术后1d、5d汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、爱丁堡产后抑郁量表(Edinburgh postnatal depression scale,EPDS)、斯坦福急性应激反应问卷(Stanford acute stress reaction questionnaire,SASRQ)、血清皮质醇(Cortisol,Cor)、肾上腺素(Epinephrine,E)水平。结果 两组术后1d、5d HAMA评分、EPDS评分均高于术前,术后观察组均显著低于对照组(P<0.05);两组术后1d、5d血清Cor、E水平、SASRQ评分较术前升高,且观察组术后Cor、E水平、SASRQ评分均显著低于对照组(P<0.05)。结论 艾司氯胺酮用于剖宫产术后镇痛能够降低抑郁、焦虑情绪以及急性应激障碍,减轻应激反应程度。
Objective To investigate the effect of esketamine on postoperative stress and emotion in patients with cesarean section.Methods A total of 120 cases of women in labor in the First People's Hospital of Xinxiang City from April 2020 to April 2022 were selected as the study subjects.Using the numerical table randomization method,they were divided into two groups,the control group was routinely analgesic after surgery,and the observation group added esketamine on the basis of the control group.The preoperative,postoperative 1d,5d Hamilton anxiety scale(HAMA),Edinburgh postnatal depression scale(EPDS),Stanford acute stress reaction questionnaire(SASRQ),the postoperative postnatal depression scale(EPDS),reaction questionnaire(SASRQ),serum cortisol(Cor)and epinephrine levels(E)were compared.Results Postoperative 1d and 5d HAMA scores and EPDS scores were higher than preoperative in both groups,and they were significantly lower in the observation group than in the control group(P<0.05).Postoperative 1d and 5d serum Cor,E levels and SASRQ scores were higher than preoperative in both groups,and postoperative Cor,E levels and SASRQ scores were significantly lower in the observation group than in the control group(P<0.05).Conclusion The use of esketamine for postoperative analgesia after cesarean delivery reduces postpartum depression and anxiety as well as acute stress disorder and decreases the degree of stress response.
作者
张艳
吴宁
高运芳
ZHANG Yan;WU Ning;GAO Yunfang(The First People's Hospital of Xinxiang City,Obstetrics Department,Xinxiang 453000,China)
出处
《国际精神病学杂志》
2024年第6期1870-1872,共3页
Journal Of International Psychiatry
关键词
艾司氯胺酮
剖宫产术
术后应激
抑郁
Escitalopram
Cesarean Section
Postoperative stress
Depression
作者简介
第一作者/通讯作者:张艳(1981.11-),女,河南新乡人,本科,副主任医师,研究方向:产科,Email:626078939@qq.com。