摘要
[目的]分析金银花提取物动物实验研究的现状、研究特点、热点趋势,为金银花提取物相关动物实验研究提供热点透视和未来药物研发建议。[方法]检索中国知网、维普、万方等中文数据库,以及Web of Science、PubMed、Embase和SinoMed等英文数据库中有关金银花提取物相关动物实验的文献,检索时间为建库至2024年3月。利用CiteSpace与VOSviewer软件对纳入文献进行证据可视化分析,包括发文趋势、作者及机构合作情况、关键词聚类、共现和突现词分析等,并绘制可视化图谱。[结果]共纳入文献1062篇,发文量总体呈现上升趋势,2022年年度发文量最多,共139篇,其中发表研究数量最多的作者为黎海芪;研究机构主要为各中医药高校和科研院所;金银花提取物动物实验研究主要集中在药理作用及作用机制方面,总体趋势是运用分子对接方式与动物实验结局指标建立联系,现阶段的研究热点主要是金银花提取物保肝和抗炎作用。[结论]金银花提取物动物实验研究应注重药物有效性,加强个人、团队间跨区域交流合作,多采用数据挖掘的方法,深入剖析金银花提取物的作用机制和规律。
[Objective]To analyze the current situation,research characteristics and hot trends of animal experimental research on Lonicera japonica Thunb.extract,and to provide hot perspective and suggestions for future drug research and development for animal experimental research on Lonicera japonica Thunb.extract.[Methods]China National Knowledge Infrastructure(CNKI),VIP,WanFang Data,Web of Science,PubMed,Embase and SinoMed databases were searched for animal experiments related to Lonicera japonica Thunb.extract from inception to March 2024.CiteSpace and VOSviewer software were used to analyze the evidence visualization of the included literature,including the trend of publication,the cooperation of authors and institutions,keyword clustering,co-occurrence and burst word analysis,and the visualization map was drawn.[Results]A total of 1062 papers were included,and the number of published papers showed an overall upward trend,with the largest number of papers published in 2022,with a total of 139 papers,among which the author with the largest number of published studies was LI Haiqi.The research institutions mainly included traditional Chinese medicine universities and research institutes.It was found that the animal experimental research of Lonicera japonica Thunb.extract mainly focused on pharmacological effects and mechanism of action,the overall trend of current animal experimental research was to use molecular docking technology to establish a relationship with the outcome indicators of animal experiments.At present,the research hotspots are mainly liver protection and anti-inflammatory effects.[Conclusion]Animal experimental research on Lonicera japonica Thunb.extract should focus on drug efficacy,strengthen cross regional communication and cooperation between individuals and teams,and use data mining methods to deeply analyze the mechanism and laws of action of Lonicera japonica Thunb.extract.
作者
吴逸菲
季昭臣
胡海殷
赵宏杰
WU Yifei;JI Zhaochen;HU Haiyin(Tianjin University of Traditional Chinese Medicine,Tianjin(301617),China;Haihe Laboratory of Modern Chinese Medicine)
出处
《浙江中医药大学学报》
2024年第12期1608-1624,共17页
Journal of Zhejiang Chinese Medical University
基金
中医药创新团队及人才支持计划-国家中医药多学科交叉创新团队项目(ZYYCXTD-D-202204)
现代中医药海河实验室科技项目(22HHZYSS00013)
金银花及其提取物基础研究项目(HX2023-14)。
关键词
中医药
金银花提取物
动物实验
研究热点
可视化分析
抗炎作用
CITESPACE
traditional Chinese medicine
Lonicera japonica Thunb.extract
animal experiment
research hotspots
visual analysis
anti-inflammatory effect
CiteSpace
作者简介
通信作者:赵宏杰,E-mail:zhaohj828@tjutcm.edu.cn。
